Document Detail

Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction.
MedLine Citation:
PMID:  18845667     Owner:  NLM     Status:  MEDLINE    
AIMS: To assess the efficacy and safety of bone marrow cell (BMC) therapy after thrombolytic therapy of an acute ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: Patients with STEMI treated with thrombolysis followed by percutaneous coronary intervention (PCI) 2-6 days after STEMI were randomly assigned to receive intracoronary BMCs (n = 40) or placebo medium (n = 40), collected and prepared 3-6 h prior PCI and injected into the infarct artery immediately after stenting. Efficacy was assessed by the measurement of global left ventricular ejection fraction (LVEF) by left ventricular angiography and 2-D echocardiography, and safety by measuring arrhythmia risk variables and restenosis of the stented vessel by intravascular ultrasound. At 6 months, BMC group had a greater absolute increase of global LVEF than placebo group, measured either by angiography (mean +/- SD increase 7.1 +/- 12.3 vs. 1.2 +/- 11.5%, P = 0.05) or by 2-D echocardiography (mean +/- SD increase 4.0 +/- 11.2 vs. -1.4 +/- 10.2%, P = 0.03). No differences were observed between the groups in the adverse clinical events, arrhythmia risk variables, or the minimal lumen diameter of the stented coronary lesion. CONCLUSION: Intracoronary BMC therapy is associated with an improvement of global LVEF and neutral effects on arrhythmia risk profile and restenosis of the stented coronary lesions in patients after thrombolytic therapy of STEMI.
Heikki V Huikuri; Kari Kervinen; Matti Niemelä; Kari Ylitalo; Marjaana Säily; Pirjo Koistinen; Eeva-Riitta Savolainen; Heikki Ukkonen; Mikko Pietilä; Juhani K E Airaksinen; Juhani Knuuti; Timo H Mäkikallio;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-10-09
Journal Detail:
Title:  European heart journal     Volume:  29     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2008-12-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  2723-32     Citation Subset:  IM    
Department of Internal Medicine, University of Oulu, Oulu, Finland.
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MeSH Terms
Arrhythmias, Cardiac* / diagnosis,  etiology
Bone Marrow Transplantation / adverse effects*
Double-Blind Method
Follow-Up Studies
Heart Rate
Injections, Intra-Arterial
Leukocytes, Mononuclear / transplantation
Middle Aged
Myocardial Infarction / drug therapy,  surgery*
Risk Assessment
Stroke Volume / physiology
Thrombolytic Therapy / methods*
Treatment Outcome
Ventricular Function, Left / drug effects,  physiology*
Miia Hyytinen-Oinas / ; Jarmo Lumme / ; Kirsi Majamaa-Voltt / ; Pekka Raaatikainen / ; Paavo Uusimaa / ; Olli-Pekka Piira / ; Timo Siitonen / ; K Kirsi Kvist-Mäkelä / ; Pirkko Huikuri / ; Päivi Karjalainen / ; P Päivi Kastell / ; Anne Lehtinen / ; T Vasankari / ; R Lautamäki / ; H Tuunanen / ; T Pelliniemi / ; Kari Ylitalo / ; Timo Mäkikallio / ; Heikki Huikuri / ; Matti Niemelä / ; Kari Kervinen / ; Kirsi Kvist-Mäkelä / ; Marjaana Sily / ; Eeva-Riitta Savolainen / ; H Tuunanen / ; T Pelliniemi /

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