Document Detail


Effects of intracoronary injection of acetylcholine on coronary arterial diameter.
MedLine Citation:
PMID:  3962897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intracoronary injection of acetylcholine on coronary arterial diameter was examined by coronary arteriography in 30 adult patients (13 men, 17 women), aged 23 to 67 years (mean 51), with normal or almost normal coronary arteriographic findings. Patients with angina pectoris, myocardial infarction and other severe cardiac diseases were excluded. Two minutes after injection of 30 to 100 micrograms of acetylcholine into the left coronary artery, significant diffuse narrowing (more than 25% reduction in diameter) of the left main trunk, the proximal, mid- and distal left anterior descending artery, and the proximal, mid- and distal left circumflex artery occurred in 1 (4%), 5 (20%), 3 (12%), 9 (36%), 6 (24%), 8 (32%) and 3 (12%) of 25 patients, respectively. After injection of 30 to 50 micrograms of acetylcholine into the right coronary artery, significant diffuse narrowing of the proximal, mid- and distal right coronary artery occurred in 5 (25%), 7 (35%) and 10 (50%) of 20 patients, respectively. However, significant diffuse dilatation (more than 25% increment in diameter) appeared in the left main trunk, left anterior descending, left circumflex and right coronary arteries in a few patients. These results indicate that acetylcholine induces coronary vasoconstriction in a significant number and coronary vasodilatation in a small number of adult humans, and that response of the coronary artery to acetylcholine varies along the course of the coronary artery.
Authors:
Y Horio; H Yasue; M Rokutanda; N Nakamura; H Ogawa; K Takaoka; K Matsuyama; T Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  57     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-05-13     Completed Date:  1986-05-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  984-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / administration & dosage,  pharmacology*
Adult
Aged
Angiography
Animals
Arrhythmias, Cardiac / chemically induced
Cardiac Pacing, Artificial
Coronary Angiography
Coronary Vessels / anatomy & histology,  drug effects*
Dilatation
Dogs
Electrocardiography
Endothelium / drug effects
Female
Heart / drug effects
Humans
Injections
Male
Middle Aged
Muscle, Smooth / drug effects
Vasoconstriction
Chemical
Reg. No./Substance:
51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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