Document Detail

Effects of intracoronary infusion of the vasoactive intestinal peptide antagonist [4Cl-D-Phe6-Leu17]VIP in the awake dog.
MedLine Citation:
PMID:  1800959     Owner:  NLM     Status:  MEDLINE    
Intracoronary infusion of [4Cl-D-Phe6-Leu17]VIP caused modest significant inhibition of the coronary vasodilation produced by intraarterial VIP, but did not significantly inhibit serotonin-induced coronary vasodilation. In addition, infusion of [4Cl-D-Phe6-Leu17]VIP did not result in significant changes in baseline coronary resistance, heart rate or left ventricular dP/dt. These findings demonstrate that [4Cl-D-Phe6-Leu17]VIP is a competitive antagonist of VIP-induced vasodilation in the canine coronary circulation, but fail to demonstrate a significant role for VIP in the regulation of resting coronary vasomotor tone, and do not support the hypothesis that VIP is a mediator of serotonin-induced coronary arteriolar dilation.
B B Quebbemann; J Rivier; R J Bache
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  12     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1991 Sep-Oct
Date Detail:
Created Date:  1992-04-21     Completed Date:  1992-04-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  989-93     Citation Subset:  IM    
Department of Medicine, University of Minnesota, Minneapolis 55455.
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MeSH Terms
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Coronary Vessels / drug effects,  physiology*
Heart Rate / drug effects
Infusions, Intra-Arterial
Muscle, Smooth, Vascular / drug effects,  physiology
Reference Values
Serotonin / administration & dosage,  pharmacology*
Vasoactive Intestinal Peptide / administration & dosage,  analogs & derivatives*,  antagonists & inhibitors,  pharmacology*
Grant Support
Reg. No./Substance:
102805-45-8/vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-; 37221-79-7/Vasoactive Intestinal Peptide; 50-67-9/Serotonin

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