| Effects of intracoronary infusion of the vasoactive intestinal peptide antagonist [4Cl-D-Phe6-Leu17]VIP in the awake dog. | |
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MedLine Citation:
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PMID: 1800959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracoronary infusion of [4Cl-D-Phe6-Leu17]VIP caused modest significant inhibition of the coronary vasodilation produced by intraarterial VIP, but did not significantly inhibit serotonin-induced coronary vasodilation. In addition, infusion of [4Cl-D-Phe6-Leu17]VIP did not result in significant changes in baseline coronary resistance, heart rate or left ventricular dP/dt. These findings demonstrate that [4Cl-D-Phe6-Leu17]VIP is a competitive antagonist of VIP-induced vasodilation in the canine coronary circulation, but fail to demonstrate a significant role for VIP in the regulation of resting coronary vasomotor tone, and do not support the hypothesis that VIP is a mediator of serotonin-induced coronary arteriolar dilation. |
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Authors:
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B B Quebbemann; J Rivier; R J Bache |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Peptides Volume: 12 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1991 Sep-Oct |
Date Detail:
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Created Date: 1992-04-21 Completed Date: 1992-04-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 989-93 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Minnesota, Minneapolis 55455. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Coronary Circulation / drug effects* Coronary Vessels / drug effects, physiology* Dogs Female Heart Rate / drug effects Infusions, Intra-Arterial Male Muscle, Smooth, Vascular / drug effects, physiology Reference Values Serotonin / administration & dosage, pharmacology* Vasoactive Intestinal Peptide / administration & dosage, analogs & derivatives*, antagonists & inhibitors, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL20598/HL/NHLBI NIH HHS; HL21872/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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102805-45-8/vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)-; 37221-79-7/Vasoactive Intestinal Peptide; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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