Document Detail


Effects of intracervical PGE2-gel on myometrial activity and cervical state in first trimester pregnancy.
MedLine Citation:
PMID:  6961477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 7 primigravidae admitted for first trimester abortion by dilatation and evacuation, 0.5 mg PGE2 in viscous gel (5 patients) or placebo gel (2 patients) was applied intracervically 6 hours prior to the operation. Throughout the treatment period intrauterine pressure was recorded. Application of placebo gel induced no cervical ripening or myometrial activation. In all patients receiving active gel, a marked improvement of the cervical state was induced by the treatment. In three cases, this priming occurred in parallel to minimal changes in myometrial activity, without regular uterine contractions. In two patients, marked uterine activation was registered due to partly extraamniotic application. It is suggested, that the PGE2-gel has a direct effect on the cervical tissues. Further, the risk of partially applying the gel in the extraamniotic space, thus stimulating the myometrium, depends on the gel volume relative to the dimensions of the cervical canal and the application technique.
In 7 primigravidae admitted for 1st trimester abortion by dilatation and evacuation, 0.5 mg prostaglandin E2 (PGE2) in a viscous gel (5 patients) or placebo gel (2 patients) was applied intracervically 6 hours prior to the operation. Throughout the treatment period, intrauterine pressure was recorded. Application of placebo gel induced no cervical ripening or myometrial activation. In all patients receiving active gel, a marked improvement of the cervical state was induced by the treatment. In 3 cases, this priming occurred parallel to minimal changes in myometrial activity without regular uterine contractions. In 2 patients, marked uterine activation was registered due to partial extraamniotic application. It is suggested that the PGE2 gel has a direct effect on cervical tissue. Furthermore, the risk of partially applying the gel in the extraamniotic space, thus stimulating the myometrium, depends on gel volume relative to the dimensions of the cervical canal and the application technique.
Authors:
A Forman; U Ulmsten; L Wingerup; J Bányai
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins     Volume:  24     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-12     Citation Subset:  IM; J    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Therapeutic / methods*
Adolescent
Adult
Cervix Uteri / drug effects*
Dinoprostone
Female
Gels
Humans
Myometrium / drug effects*
Pregnancy
Pregnancy Trimester, First
Prostaglandins E / administration & dosage,  pharmacology*
Uterine Contraction / drug effects
Uterus / drug effects*
Chemical
Reg. No./Substance:
0/Gels; 0/Prostaglandins E; 363-24-6/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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