Document Detail

Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism.
MedLine Citation:
PMID:  1996719     Owner:  NLM     Status:  MEDLINE    
Our objective was to find out if central injection of neuropeptide Y (NPY) would alter brown fat thermogenesis and white fat lipoprotein lipase activity. The following three groups of Sprague-Dawley rats received five injections over 24 h into the right lateral ventricle: 1) NPY (5 micrograms/injection) and ad libitum food; 2) NPY (5 micrograms/injection) and food restricted to control intake; 3) saline injection and ad libitum food. The NPY ad libitum-fed group consumed more food than the saline controls or NPY food-restricted animals. Brown fat thermogenic activity, assessed by GDP binding, was decreased relative to saline controls in both NPY-treated groups. White fat lipoprotein lipase activity was greatly increased in both NPY treatment groups compared with saline controls. The NPY effects on brown and white fat were not explained by measures of serum insulin, glucagon, glucose, or other metabolites. In a follow-up experiment, we asked whether food was necessary for expression of the NPY effects. Brown fat mitochondrial GDP binding indicated NPY effect even when no food was ingested. We conclude that intracerebroventricular administration of NPY promotes white fat lipid storage and decreases brown fat thermogenesis in addition to its known effect of stimulating food intake.
C J Billington; J E Briggs; M Grace; A S Levine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  260     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-22     Completed Date:  1991-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R321-7     Citation Subset:  IM    
Department of Research, Minneapolis Veterans Administration Medical Center 55417.
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MeSH Terms
Adipose Tissue / enzymology
Adipose Tissue, Brown / anatomy & histology,  metabolism
Body Temperature Regulation / drug effects
Brain / physiology*
Eating / drug effects
Energy Metabolism / drug effects*,  physiology
Guanosine Diphosphate / metabolism
Hormones / blood
Injections, Intraventricular
Lipoprotein Lipase / metabolism
Neuropeptide Y / pharmacology*
Organ Size
Rats, Inbred Strains
Reg. No./Substance:
0/Hormones; 0/Neuropeptide Y; 146-91-8/Guanosine Diphosphate; EC Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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