| Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. | |
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MedLine Citation:
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PMID: 1996719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our objective was to find out if central injection of neuropeptide Y (NPY) would alter brown fat thermogenesis and white fat lipoprotein lipase activity. The following three groups of Sprague-Dawley rats received five injections over 24 h into the right lateral ventricle: 1) NPY (5 micrograms/injection) and ad libitum food; 2) NPY (5 micrograms/injection) and food restricted to control intake; 3) saline injection and ad libitum food. The NPY ad libitum-fed group consumed more food than the saline controls or NPY food-restricted animals. Brown fat thermogenic activity, assessed by GDP binding, was decreased relative to saline controls in both NPY-treated groups. White fat lipoprotein lipase activity was greatly increased in both NPY treatment groups compared with saline controls. The NPY effects on brown and white fat were not explained by measures of serum insulin, glucagon, glucose, or other metabolites. In a follow-up experiment, we asked whether food was necessary for expression of the NPY effects. Brown fat mitochondrial GDP binding indicated NPY effect even when no food was ingested. We conclude that intracerebroventricular administration of NPY promotes white fat lipid storage and decreases brown fat thermogenesis in addition to its known effect of stimulating food intake. |
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Authors:
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C J Billington; J E Briggs; M Grace; A S Levine |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 260 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-22 Completed Date: 1991-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R321-7 Citation Subset: IM |
Affiliation:
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Department of Research, Minneapolis Veterans Administration Medical Center 55417. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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enzymology Adipose Tissue, Brown / anatomy & histology, metabolism Animals Body Temperature Regulation / drug effects Brain / physiology* Eating / drug effects Energy Metabolism / drug effects*, physiology Guanosine Diphosphate / metabolism Hormones / blood Injections, Intraventricular Lipoprotein Lipase / metabolism Male Neuropeptide Y / pharmacology* Organ Size Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 0/Neuropeptide Y; 146-91-8/Guanosine Diphosphate; EC 3.1.1.34/Lipoprotein Lipase |
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