| Effects of intracerebroventricular infusion of angiotensin II and related peptides on water and sodium ingestion and excretion. | |
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MedLine Citation:
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PMID: 3228647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the present study was to investigate the effects of an angiotensin II (AII) analogue, Des-Asp1-AII and of two competitive blockers, [Leu8]-AII and [octanoyl-Leu8]-AII, infused intracerebroventricularly on the ingestion of water and of a 3% NaCl solution, as well as on diuresis and natriuresis in normal rats and in adrenalectomized and deoxycorticosterone (DOCA)-treated rats. Both AII and Des-Asp1-AII increased water and 3% NaCl intake and increased urine and Na+ excretion, the effect of AII being more intense. Except for 3% NaCl, the responses of all other parameters were totally or partially reduced by previous treatment with [Leu8]-AII or [octanoyl-Leu8]-AII. Subcutaneous DOCA injection caused water ingestion. Previous treatment with DOCA increased the response to AII for the ingestion of 3% NaCl and inhibited sodium excretion. The results obtained for adrenalectomized rats treated with DOCA, AII and analogous agonists did not differ from those observed in normal rats. These data suggest a possible synergism between the cerebral and renal renin-angiotensin systems in the regulation of the physiological parameters studied. |
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Authors:
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J R Gonçalves; L A Camargo; J V Menani; W A Saad; W A Saad; A Renzi; L A De Luca Júnior |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 21 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-04-20 Completed Date: 1989-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 615-9 Citation Subset: IM |
Affiliation:
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Departamento de Ciências Fisiológicas, Faculdade de Odontologia de Araraquara, UNESP, SP, Brasil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenalectomy Angiotensin II / analogs & derivatives*, pharmacology Angiotensin III / pharmacology* Animals Desoxycorticosterone / therapeutic use Diuresis / drug effects* Drinking / drug effects* Injections, Intraventricular Male Natriuresis / drug effects* Rats Rats, Inbred Strains Sodium Chloride / metabolism |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 12687-51-3/Angiotensin III; 64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride; 9088-02-2/angiotensin II, Ile(8)- |
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