| Effects of intra-uterine and early extra-uterine malnutrition on seizure threshold and hippocampal morphometry of pup rats. | |
| | |
MedLine Citation:
|
PMID: 21943953 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We evaluate the influence of different malnutrition paradigms (intra-uterine x extra-uterine) in body and brain weight, in seizure threshold and in hippocampus morphometry, in developing rats. Intra-uterine malnutrition model consisted in reduction by half of the ration offered to pregnant female; extrauterine malnutrition consisted of progressive limitation of lactation, from P2 to P15. Seizure induction was accomplished by exposure to flurothyl, at P15. At the same day animals were sacrificed. Morphometric analysis was based on hippocampal pyramidal and granular cells estimate number, through volume calculation and cellular density. Extra-uterine malnutrition significantly reduced pups body and brain weight, seizure threshold and neuronal number in CA4 region only. Intra-uterine malnutrition reduced neuronal number in CA2, CA4 and DG regions regarding well-nourished and extra-uterine malnourished animals. In CA3, CA4 and dentate gyrus, a significant cell increase was observed in groups exposed to seizures, regarding similar control groups. |
| | |
Authors:
|
Mariana Lorenzet Florian; Magda Lahorgue Nunes |
Related Documents
:
|
9093163 - Brain penetration and neurological effects of gadobenate dimeglumine in the rat. 17021813 - Distribution of the 5-ht(1a) receptor antagonist [ (18)f]fpway in blood and brain of th... 22262123 - Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats. |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Nutritional neuroscience Volume: 14 ISSN: 1476-8305 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: - |
Other Details:
|
Languages: ENG Pagination: 151-158 Citation Subset: - |
Affiliation:
|
Neurosciences Laboratory, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) School of Medicine, Porto Alegre, RS, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improvement and Characterization of the Adhesion of Electrospun PLDLA Nanofibers on PLDLA-Based 3D O...
Next Document: School foodservice personnel's struggle with using labels to identify whole-grain foods.