Document Detail


Effects of intra-arterially infused adenosine triphosphate (ATP) on release of vasoactive intestinal polypeptide (VIP) from the gastrointestinal tract of the cat.
MedLine Citation:
PMID:  4091009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Close i.a. infusions of ATP were made to the stomach, the small intestine or the colon in the cat. The vascular reactions were followed by recording arterial pressure and total venous outflow continuously and the release of VIP was estimated intermittently from arterio-venous concentration differences and blood flow. In all experiments ATP caused a vasodilatation and an increased release of VIP into blood. In control experiments it was shown that evoking a vasodilatation of the same magnitude by close i.a. infusions of isoprenaline or papaverine did not evoke any similar release of VIP. It is concluded that the infused ATP released VIP from the different parts of the gastrointestinal tract. Possible mechanisms underlying this effect are tentatively discussed.
Authors:
A Sjöqvist; J Fahrenkrug; M Hemlin; M Jodal; O Lundgren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  125     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-03-12     Completed Date:  1986-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  693-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / administration & dosage*
Animals
Cats
Colon / blood supply,  drug effects*
Infusions, Intra-Arterial
Intestine, Small / blood supply,  drug effects*
Stomach / blood supply,  drug effects*
Vasoactive Intestinal Peptide / metabolism*
Vasodilation / drug effects
Chemical
Reg. No./Substance:
37221-79-7/Vasoactive Intestinal Peptide; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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