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Effects of intra-abdominal pressure on respiratory system mechanics in mechanically ventilated rats.
MedLine Citation:
PMID:  22138515     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the effects of intra-abdominal pressure on respiratory system compliance at different PEEP levels. 20 ventilated rats underwent four pressure levels (7, 9, 11, 13mmHg) of helium pneumoperitoneum and were allocated to one of the four PEEP groups (0, 3, 6 and 9cmH(2)O). From the expiratory pressure-volume curve the mathematical inflection point (MIP) was calculated. Volume dependent compliance was analyzed using the SLICE-method. MIP-pressure correlated to the intra-abdominal pressure (r(2)=0.94, p<0.001). Peak inspiratory pressure increased with intra-abdominal pressure, and was lower after recruitment-maneuvers (p<0.001). The compliance gain following recruitment-maneuvers depended on PEEP, intra-abdominal pressure and intratidal volume (all p<0.001). Mean arterial pressure was independent of PEEP (p=0.068) and intra-abdominal pressure (p=0.293). Volume dependent compliance courses varied according to PEEP and intra-abdominal pressure. The level of intra-abdominal pressure alters respiratory system mechanics in healthy lungs. Intratidal compliance can be used to guide the PEEP adjustment in intra-abdominal hypertension. If counterbalanced by PEEP, elevated intra-abdominal pressure has no negative effects on oxygenation or hemodynamics.
Authors:
Hanna Runck; Stefan Schumann; Sabine Tacke; Jörg Haberstroh; Josef Guttmann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-25
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Division for Experimental Anesthesiology, University Medical Center Freiburg, Germany.
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