Document Detail

Effects of intra-abdominal pressure on respiratory system mechanics in mechanically ventilated rats.
MedLine Citation:
PMID:  22138515     Owner:  NLM     Status:  Publisher    
We investigated the effects of intra-abdominal pressure on respiratory system compliance at different PEEP levels. 20 ventilated rats underwent four pressure levels (7, 9, 11, 13mmHg) of helium pneumoperitoneum and were allocated to one of the four PEEP groups (0, 3, 6 and 9cmH(2)O). From the expiratory pressure-volume curve the mathematical inflection point (MIP) was calculated. Volume dependent compliance was analyzed using the SLICE-method. MIP-pressure correlated to the intra-abdominal pressure (r(2)=0.94, p<0.001). Peak inspiratory pressure increased with intra-abdominal pressure, and was lower after recruitment-maneuvers (p<0.001). The compliance gain following recruitment-maneuvers depended on PEEP, intra-abdominal pressure and intratidal volume (all p<0.001). Mean arterial pressure was independent of PEEP (p=0.068) and intra-abdominal pressure (p=0.293). Volume dependent compliance courses varied according to PEEP and intra-abdominal pressure. The level of intra-abdominal pressure alters respiratory system mechanics in healthy lungs. Intratidal compliance can be used to guide the PEEP adjustment in intra-abdominal hypertension. If counterbalanced by PEEP, elevated intra-abdominal pressure has no negative effects on oxygenation or hemodynamics.
Hanna Runck; Stefan Schumann; Sabine Tacke; Jörg Haberstroh; Josef Guttmann
Related Documents :
15492475 - Increased plasma 8-isoprostane levels in hypertensive subjects: the tsurugaya project.
1410185 - Family history of hypertension and cardiovascular changes during high and low affect pr...
15902345 - The metabolic syndrome in hypertensive and normotensive subjects: the isfahan healthy h...
22001985 - Long-term use of low-dose spironolactone in spontaneously hypertensive rats: effects on...
23397665 - Combination of clonidine sedation and spontaneous breathing-pressure support upon acute...
23774335 - End-expiratory occlusion test predicts preload responsiveness independently of positive...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-25
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Division for Experimental Anesthesiology, University Medical Center Freiburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Functional characterization of CD4+ T cells in aplastic anemia.
Next Document:  The apoptosis inducing effect of Glycosmis pentaphylla (Retz.) Correa and its influence on gene expr...