| Effects of intra-abdominal pressure on liver function assessed with the LiMON in critically ill patients. | |
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MedLine Citation:
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PMID: 21443832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Intra-abdominal pressure (IAP) and intra-abdominal hypertension (IAH) are associated with significant morbidity and mortality in critically ill patients. Our aim was to assess the effects of IAH on liver function using the noninvasive liver function monitoring system LiMON and to assess the prognostic value of IAP in critically ill patients. METHODS: We conducted a retrospective analysis of critically ill patients who were treated in the intensive care unit (ICU). The IAP and indocyanine green plasma disappearance rate (ICG-PDR) measurements were made within 24 hours after admission to the ICU and repeated 12 hours later. Intra-abdominal pressure was measured via a Foley bladder catheter, and ICG elimination tests were conducted concurrently using the LiMON. RESULTS: We included 30 critically ill patients (17 women and 13 men aged 28-89 yr) in our analysis. Statistical analysis showed that the baseline IAP values were significantly higher among nonsurvivors than survivors (19.38 [standard deviation; SD 2.08] v. 13.07 [SD 0.99]). The twelfth-hour IAP values were higher than baseline measurements among nonsurvivors (21.50 [SD 1.96]) and lower than baseline measurements among survivors (11.71 [SD 1.54]); the difference between groups was significant (p < 0.001). The baseline ICG-PDR values were significantly lower among nonsurvivors than survivors (10.86 [SD 3.35] v. 24.51 [SD 6.78]), and the twelfth-hour ICGPDR values were decreased in all groups; the difference between groups was significant (p < 0.001). CONCLUSION: Our results suggest that measurement of ICG-PDR with the LiMON is a good predictor of the effects of IAP on liver function and, thus, can be recommended for the evaluation of critically ill patients. |
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Authors:
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Mehmet Turan Inal; Dilek Memis; Y Atakan Sezer; Meltem Atalay; Abdullah Karakoc; Necdet Sut |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of surgery. Journal canadien de chirurgie Volume: 54 ISSN: 1488-2310 ISO Abbreviation: Can J Surg Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-25 Completed Date: 2011-07-20 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0372715 Medline TA: Can J Surg Country: Canada |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Trakya University Medical Faculty, Edirne, Turkey. mehturinal@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Cavity
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physiopathology* Adult Aged Aged, 80 and over Alanine Transaminase / blood* Aspartate Aminotransferases / blood* Biological Markers / blood Critical Illness / mortality* Female Humans Hypertension / physiopathology* Intensive Care / methods Intensive Care Units Liver Function Tests / methods* Male Middle Aged Predictive Value of Tests Prognosis Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
| Comments/Corrections | |
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