| Effects of intra-abdominal pressure increase on intestinal ischemia and bacterial translocation in experimental sepsis model. | |
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MedLine Citation:
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PMID: 21858390 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the safety of laparoscopic intervention for diagnosis and treatment at 8 mm Hg pressure in one-hour period on acute peritonitis related intra-abdominal sepsis model. METHODS: In this study, we included 32 female Wistar-Albino rats, weighing 250 +/- 20 g, and divided them into 4 groups. This study was conducted in Istanbul University Experimental Medical Research Institution (DETAE) laboratory from April to May 2009. Intra-abdominal sepsis was created with intraperitoneal (i.p.) one mL (109 CFU/mL) Escherichia coli (E. coli) injection, and pneumoperitoneum was formed with CO2 insufflation at 8 mm Hg pressure for one hour i.p. The rats were administered with: Group 1 - one mL i.p. isotonic saline; Group 2 - one mL i.p. isotonic saline + pneumoperitoneum; Group 3 - i.p E. coli; and Group 4 - i.p. E.coli + pneumoperitoneum. Data were analyzed using the Statistical Package for Social Sciences version 15 for Windows (SPSS Inc, Chicago, IL, USA). RESULTS: Fever and leukocyte values were considered high in Groups 3 and 4 compared with Groups 1 and 2 (p=0.001). The administered reproduction ratio of the E. coli strain was determined as 0% in Groups 1 and 2, and 100% in Groups 3 and 4. CONCLUSION: In this study, as pneumoperitoneum was formed for one hour at 8 mm Hg pressure, in case of intra-abdominal derived sepsis where emergency intervention is needed, we consider that laparoscopic approaches with low pressure may be used safely for diagnosis and treatment. |
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Authors:
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Ugur Kesici; Sevgi Kesici; Erdal Polat; Birol Agca; Ulku A Turkmen; Deniz Ozcan; Musa K Sari |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Saudi medical journal Volume: 32 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 813-7 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Akcaabat State Hospital, Ministry of Health, Trabzon, Turkey. Tel. +90 (462) 2213085. Fax. +90 (462) 2277779. E-mail: ugurkesici77@mynet.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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