Document Detail

Effects of interpregnancy interval on blood pressure in consecutive pregnancies.
MedLine Citation:
PMID:  18495629     Owner:  NLM     Status:  MEDLINE    
The lower risk of preeclampsia observed in parous women has prompted a hypothesis that cardiovascular adaptation from a first pregnancy has ongoing benefits which contribute to a reduced risk of preeclampsia in the second pregnancy. However, how the interpregnancy interval affects mean arterial pressure (MAP) as an indicator of cardiovascular adaptation in subsequent pregnancies has not been well studied. The authors examined the effect of interpregnancy interval on MAP in consecutive pregnancies using data from the Collaborative Perinatal Project (1959-1965) and a semiparametric random-effects regression model. Prenatal MAP measurements were available for 533 women with both first and second births. MAP was lower in the second pregnancy (by approximately 2 mmHg) for very short interpregnancy intervals. However, this difference diminished when the interval increased, and it totally disappeared for intervals longer than 2 years. The authors conclude that although MAP is lower in the second pregnancy than in the first pregnancy, the effect persists for only a short time. It is therefore unlikely that mechanisms involving MAP as an indicator of cardiovascular adaptation contribute appreciably to the reduced risk of preeclampsia in subsequent pregnancies. However, it does not rule out the possibility that other mechanisms of cardiovascular adaptation persist longer.
Rafael T Mikolajczyk; Jun Zhang; Jessie Ford; Jagteshwar Grewal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2008-05-20
Journal Detail:
Title:  American journal of epidemiology     Volume:  168     ISSN:  1476-6256     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-08-21     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  IM    
Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
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MeSH Terms
Adaptation, Physiological / physiology
Birth Intervals*
Blood Pressure / physiology*
Blood Pressure Determination
Blood Volume
Maternal Age
Pre-Eclampsia / epidemiology*,  etiology,  physiopathology,  prevention & control
Prospective Studies
Regression Analysis
Risk Factors
Smoking / adverse effects,  epidemiology
Time Factors
United States / epidemiology
Vascular Capacitance
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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