|Effects of interpregnancy interval on blood pressure in consecutive pregnancies.|
|PMID: 18495629 Owner: NLM Status: MEDLINE|
|The lower risk of preeclampsia observed in parous women has prompted a hypothesis that cardiovascular adaptation from a first pregnancy has ongoing benefits which contribute to a reduced risk of preeclampsia in the second pregnancy. However, how the interpregnancy interval affects mean arterial pressure (MAP) as an indicator of cardiovascular adaptation in subsequent pregnancies has not been well studied. The authors examined the effect of interpregnancy interval on MAP in consecutive pregnancies using data from the Collaborative Perinatal Project (1959-1965) and a semiparametric random-effects regression model. Prenatal MAP measurements were available for 533 women with both first and second births. MAP was lower in the second pregnancy (by approximately 2 mmHg) for very short interpregnancy intervals. However, this difference diminished when the interval increased, and it totally disappeared for intervals longer than 2 years. The authors conclude that although MAP is lower in the second pregnancy than in the first pregnancy, the effect persists for only a short time. It is therefore unlikely that mechanisms involving MAP as an indicator of cardiovascular adaptation contribute appreciably to the reduced risk of preeclampsia in subsequent pregnancies. However, it does not rule out the possibility that other mechanisms of cardiovascular adaptation persist longer.|
|Rafael T Mikolajczyk; Jun Zhang; Jessie Ford; Jagteshwar Grewal|
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|Type: Journal Article; Research Support, N.I.H., Intramural Date: 2008-05-20|
|Title: American journal of epidemiology Volume: 168 ISSN: 1476-6256 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2008 Aug|
|Created Date: 2008-08-11 Completed Date: 2008-08-21 Revised Date: 2013-06-05|
Medline Journal Info:
|Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States|
|Languages: eng Pagination: 422-6 Citation Subset: IM|
|Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.|
|APA/MLA Format Download EndNote Download BibTex|
Blood Pressure / physiology*
Blood Pressure Determination
Pre-Eclampsia / epidemiology*, etiology, physiopathology, prevention & control
Smoking / adverse effects, epidemiology
United States / epidemiology
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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