Document Detail


Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease.
MedLine Citation:
PMID:  15878725     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with Parkinson's disease (PD) exhibit deficits in perceptual and motor timing as well as impairments in memory and attentional processes that are related to dysfunction of dopaminergic systems in the basal ganglia. The aim of the present study was to assess the relationships existing between impaired duration judgments and defective memory and attention in PD patients. We compared time performance of medicated PD patients and control subjects on a duration reproduction task that is highly memory-dependent, and on a duration production task that could reveal effects of changes in the speed of internal time-keeping mechanisms. Each task was performed in a control counting condition and in a condition requiring divided attention between the temporal task and a concurrent reading task. Moreover, PD patients and control subjects were assessed on memory and attention using a battery of neuropsychological tests. The results revealed that in the concurrent reading condition of the reproduction task, duration judgments tended to be more variable in PD patients than in control subjects. Moreover, variability of duration reproductions was correlated with both measures of memory and of disease severity. In the concurrent reading condition of the production task, duration judgments were significantly shorter in PD patients than in control subjects, and accuracy of duration productions was correlated with scores on sub-tests of short-term memory. The findings suggest that the administration of dopamine did not entirely remove the memory deficits in PD patients. Moreover, DA treatment would have abnormally accelerated the rate of the internal clock leading to shorter duration productions in PD patients. The whole results indicate that dopamine administration in patients might have overshadowed the slowing rate of the internal clock usually reported in non medicated PD patients, without entirely restoring all of the memory functions.
Authors:
Séverine Perbal; Bernard Deweer; Bernard Pillon; Marie Vidailhet; Bruno Dubois; Viviane Pouthas
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain and cognition     Volume:  58     ISSN:  0278-2626     ISO Abbreviation:  Brain Cogn     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8218014     Medline TA:  Brain Cogn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-48     Citation Subset:  IM    
Affiliation:
Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, Hôpital de la Salpêtrière, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Attention / physiology
Chronobiology Disorders / complications,  physiopathology*
Female
Humans
Male
Memory / physiology*
Memory Disorders / complications,  physiopathology*
Middle Aged
Neuropsychological Tests
Parkinson Disease / complications,  physiopathology*
Reference Values
Severity of Illness Index
Time Perception / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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