| Effects of internal clock and memory disorders on duration reproductions and duration productions in patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 15878725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with Parkinson's disease (PD) exhibit deficits in perceptual and motor timing as well as impairments in memory and attentional processes that are related to dysfunction of dopaminergic systems in the basal ganglia. The aim of the present study was to assess the relationships existing between impaired duration judgments and defective memory and attention in PD patients. We compared time performance of medicated PD patients and control subjects on a duration reproduction task that is highly memory-dependent, and on a duration production task that could reveal effects of changes in the speed of internal time-keeping mechanisms. Each task was performed in a control counting condition and in a condition requiring divided attention between the temporal task and a concurrent reading task. Moreover, PD patients and control subjects were assessed on memory and attention using a battery of neuropsychological tests. The results revealed that in the concurrent reading condition of the reproduction task, duration judgments tended to be more variable in PD patients than in control subjects. Moreover, variability of duration reproductions was correlated with both measures of memory and of disease severity. In the concurrent reading condition of the production task, duration judgments were significantly shorter in PD patients than in control subjects, and accuracy of duration productions was correlated with scores on sub-tests of short-term memory. The findings suggest that the administration of dopamine did not entirely remove the memory deficits in PD patients. Moreover, DA treatment would have abnormally accelerated the rate of the internal clock leading to shorter duration productions in PD patients. The whole results indicate that dopamine administration in patients might have overshadowed the slowing rate of the internal clock usually reported in non medicated PD patients, without entirely restoring all of the memory functions. |
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Authors:
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Séverine Perbal; Bernard Deweer; Bernard Pillon; Marie Vidailhet; Bruno Dubois; Viviane Pouthas |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain and cognition Volume: 58 ISSN: 0278-2626 ISO Abbreviation: Brain Cogn Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-09 Completed Date: 2005-07-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8218014 Medline TA: Brain Cogn Country: United States |
Other Details:
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Languages: eng Pagination: 35-48 Citation Subset: IM |
Affiliation:
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Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, Hôpital de la Salpêtrière, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Attention / physiology Chronobiology Disorders / complications, physiopathology* Female Humans Male Memory / physiology* Memory Disorders / complications, physiopathology* Middle Aged Neuropsychological Tests Parkinson Disease / complications, physiopathology* Reference Values Severity of Illness Index Time Perception / physiology* |
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