Document Detail

Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers.
MedLine Citation:
PMID:  16990498     Owner:  NLM     Status:  MEDLINE    
The effects of concurrent hypoxic/endurance training on mitochondrial respiration in permeabilized fibers in trained athletes were investigated. Eighteen endurance athletes were divided into two training groups: normoxic (Nor, n = 8) and hypoxic (H, n = 10). Three weeks (W1-W3) of endurance training (5 sessions of 1 h to 1 h and 30 min per week) were completed. All training sessions were performed under normoxic [160 Torr inspired Po(2) (Pi(O(2)))] or hypoxic conditions ( approximately 100 Torr Pi(O(2)), approximately 3,000 m) for Nor and H group, respectively, at the same relative intensity. Before and after the training period, an incremental test to exhaustion in normoxia was performed, muscle biopsy samples were taken from the vastus lateralis, and mitochondrial respiration in permeabilized fibers was measured. Peak power output (PPO) increased by 7.2% and 6.6% (P < 0.05) for Nor and H, respectively, whereas maximal O(2) uptake (Vo(2 max)) remained unchanged: 58.1 +/- 0.8 vs. 61.0 +/- 1.2 and 58.5 +/- 0.7 vs. 58.3 +/- 0.6 for Nor and H, respectively, between pretraining (W0) and posttraining (W4). Maximal ADP-stimulated mitochondrial respiration significantly increased for glutamate + malate (6.27 +/- 0.37 vs. 8.51 +/- 0.33 mumol O(2).min(-1).g dry weight(-1)) and significantly decreased for palmitate + malate (3.88 +/- 0.23 vs. 2.77 +/- 0.08 mumol O(2).min(-1).g dry weight(-1)) in the H group. In contrast, no significant differences were found for the Nor group. The findings demonstrate that 1) a 3-wk training period increased the PPO at sea level without any changes in Vo(2 max), and 2) a 3-wk hypoxic exercise training seems to alter the intrinsic properties of mitochondrial function, i.e., substrate preference.
Belle Roels; Claire Thomas; David J Bentley; Jacques Mercier; Maurice Hayot; Grégoire Millet
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-21
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  102     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-03-13     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-86     Citation Subset:  IM    
Unite Propre de Recherche de l'Enseignement Superieur-Equipe d'Accueil 3759 "Multidisciplinary Approach of Doping", Montpellier, France.
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MeSH Terms
3-Hydroxyacyl CoA Dehydrogenases / metabolism
Amino Acids / metabolism*
Anoxia / metabolism*,  physiopathology*
Cell Respiration / physiology
Citrate (si)-Synthase / metabolism
Exercise / physiology*
Fatty Acids / metabolism*
Glutamic Acid / metabolism
Malates / metabolism
Mitochondria, Muscle / physiology
Muscle, Skeletal / metabolism*,  pathology,  physiology
Oxygen Consumption / physiology
Physical Endurance / physiology
Reg. No./Substance:
0/Amino Acids; 0/Fatty Acids; 0/Malates; 56-86-0/Glutamic Acid; 6915-15-7/malic acid; EC CoA Dehydrogenases; EC (si)-Synthase

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