Document Detail

Effects of intermittent hypoxia on the heart.
MedLine Citation:
PMID:  17511587     Owner:  NLM     Status:  MEDLINE    
Obstructive sleep apnea (OSA) is associated with cardiovascular diseases such as hypertension through mechanisms involving intermittent hypoxia (IH). However, it is not yet clear whether IH directly affects the heart. In a mouse model of OSA, we found that IH causes time-dependent alterations of the susceptibility of the heart to oxidative stress. Acute IH can exert preconditioning-like cardioprotection, in part, through the transcriptional activation of genes such as bcl-x(L) and gata4. We cloned the mouse gata4 promoter and identified an IH-responsive region. The exposure of mice to prolonged IH results in the increased susceptibility of the heart to ischemia-reperfusion injury by increasing the oxidative stress status. This might resemble conditions of OSA patients. In our mouse model, further exposure to prolonged IH allowed reversal of the enhancement of myocardial damage. Understanding the complex effects of IH on the heart should help ultimately to develop therapeutic strategies against OSA-induced complications.
Ah-Mee Park; Hiroko Nagase; Shilpashree Vinod Kumar; Yuichiro J Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  9     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-06-18     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  723-9     Citation Subset:  IM    
Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20057, USA.
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MeSH Terms
Adaptation, Biological
Anoxia / genetics,  metabolism,  pathology*
Heart Diseases / genetics,  metabolism,  pathology*
Oxidative Stress
Sleep Apnea Syndromes / pathology
Grant Support

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