| Effects of intermittent hypoxia on the heart. | |
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MedLine Citation:
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PMID: 17511587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obstructive sleep apnea (OSA) is associated with cardiovascular diseases such as hypertension through mechanisms involving intermittent hypoxia (IH). However, it is not yet clear whether IH directly affects the heart. In a mouse model of OSA, we found that IH causes time-dependent alterations of the susceptibility of the heart to oxidative stress. Acute IH can exert preconditioning-like cardioprotection, in part, through the transcriptional activation of genes such as bcl-x(L) and gata4. We cloned the mouse gata4 promoter and identified an IH-responsive region. The exposure of mice to prolonged IH results in the increased susceptibility of the heart to ischemia-reperfusion injury by increasing the oxidative stress status. This might resemble conditions of OSA patients. In our mouse model, further exposure to prolonged IH allowed reversal of the enhancement of myocardial damage. Understanding the complex effects of IH on the heart should help ultimately to develop therapeutic strategies against OSA-induced complications. |
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Authors:
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Ah-Mee Park; Hiroko Nagase; Shilpashree Vinod Kumar; Yuichiro J Suzuki |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: 9 ISSN: 1523-0864 ISO Abbreviation: Antioxid. Redox Signal. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-21 Completed Date: 2007-06-18 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: United States |
Other Details:
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Languages: eng Pagination: 723-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20057, USA. ys82@georgetown.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Biological Animals Anoxia / genetics, metabolism, pathology* Heart Diseases / genetics, metabolism, pathology* Humans Oxidative Stress Sleep Apnea Syndromes / pathology |
| Grant Support | |
ID/Acronym/Agency:
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HL67340/HL/NHLBI NIH HHS; HL72844/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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