Document Detail


Effects of interleukin-6 T15A single nucleotide polymorphism on baseline peritoneal solute transport rate in incident peritoneal dialysis patients.
MedLine Citation:
PMID:  19164257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the genetic effects of various inflammatory cytokines on peritoneal solute transport rate (PSTR) in incident Korean peritoneal dialysis (PD) patients. DESIGN: Case-control association study. METHODS: 132 patients with baseline peritoneal equilibration test within 1-3 months after starting PD were enrolled. We analyzed the influence of single nucleotide polymorphisms (SNPs) of interleukin-6 (IL-6; -572G/C, T15A), tumor necrosis factor-alpha (TNF-alpha; -1031C/T, -863C/A, -308G/A), and IL-10 (-1082A/G, -592A/C) on baseline PSTR. Clinical parameters such as age, gender, presence of diabetes mellitus, comorbidity, C-reactive protein, and residual renal function were also included as covariates. RESULTS: The T15A SNP of IL-6 (rs13306435) was associated with PSTR. Patients with TA genotype (n=18) had significantly lower D4/P creatinine (0.65+/-0.087 vs 0.73+/-0.110, p=0.0046) and higher D4/D0 glucose (0.39+/-0.174 vs 0.31+/-0.119, p=0.027) than patients with TT genotype (n=114). The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine (r2=0.1294, p<0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7+/-14.42 vs 116.8+/-88.91 pg/minute, p=0.0358). By multiple logistic regression, TA genotype was negatively associated with a higher PSTR (high or high average; odds ratio 0.18; 95% confidence interval 0.048-0.666). CONCLUSIONS: In incident Korean PD patients, T15A polymorphism of IL-6 is associated with dialysate IL-6 concentration and baseline PSTR.
Authors:
Young-Hwan Hwang; Min-Jeong Son; Jaeseok Yang; Kiwon Kim; Wookyung Chung; Kwon-Wook Joo; Yonsu Kim; Curie Ahn; Kook-Hwan Oh
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  29     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:    2009 Jan-Feb
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Eulji General Hospital, and Seoul National University, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Biological Transport, Active / genetics
DNA / genetics*
Dialysis Solutions / chemistry,  pharmacokinetics*
Female
Follow-Up Studies
Genotype
Humans
Interleukin-6 / analysis,  genetics*,  metabolism
Kidney Failure, Chronic / metabolism,  therapy*
Korea
Male
Middle Aged
Peritoneal Dialysis / methods*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Dialysis Solutions; 0/Interleukin-6; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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