Document Detail


Effects of interleukin-2 on the mechanical restitution and post-rest contraction in rat ventricular papillary muscle.
MedLine Citation:
PMID:  17271078     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
To determine whether application of interleukin-2 (IL-2) alters function of sarcoplasmic reticulum (SR), we measured mechanical restitution and post-rest potentiation (PRP) in isolated rat papillary muscles. Mechanical restitution curves were constructed by interpolating extrasystoles at different test intervals following a train of steady state beats. In control group, the maximal PRP was reached after 60-120s of rest and the maximal potentiation factor was 2.36 +/- 0.23. IL-2 at 200 U/ml decreased the steady-state force of contraction to 56.4 +/- 7.2% of pre-drug control. But the time constant of recovery of steady-state force was not altered after IL-2. IL-2 decreased PRP at all intervals, shifted the potentiation curve parallel to lower values. But the potentiation was enhanced when compared with pre-rest control value in the presence of IL-2. In papillary muscle treated with IL-2, the onset of maximal PRP was delayed and the potentiation factor after 300s was 4.72 +/- 0.58 times that at the steady-state. Recirculation fraction of calcium calculated from the decay of PRP was 0.78 +/- 0.09 in control and 0.59 +/- 0.08 after IL-2 treatment. We conclude that IL-2 decreases the function of SR, which suggests that an impaired function of SR may contribute to the negative inotropic effect of IL-2.
Authors:
G-H Lin; H-L Ru; P-L Wu; C-M Cao; Q Xia
Related Documents :
15845588 - Age is no barrier to muscle structural, biochemical and angiogenic adaptations to train...
23007178 - Review of exercise studies in breast cancer survivors: attention to principles of exerc...
22978198 - Implicit and explicit exercise and sedentary identity.
6785718 - Peripheral markers of thyroid status unaffected by endurance training in rats.
9034268 - High-frequency oscillatory ventilation with partial liquid ventilation in a model of ac...
3591688 - Relation of blood pressure during exercise to anaerobic metabolism.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  5     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2004  
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-06-08     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3628-31     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The mitochondrial calcium uniporter participates in ischemia/reperfusion injury and in cardioprotect...
Next Document:  Negative inotropic effect of interleukin-2 in the isolated ventricular myocytes: role of NO/sGC path...