Document Detail

Effects of interleukin-15 on lipid oxidation: disposal of an oral [(14)C]-triolein load.
MedLine Citation:
PMID:  16458591     Owner:  NLM     Status:  MEDLINE    
Interleukin 15 (IL-15) has previously been shown to have important effects on lipid metabolism in adipose tissue, particularly influencing the rate of the de novo fatty acid synthesis. The results presented here show that chronic administration to rats (100 microg/kg body weight) has important effects on the metabolic fate of an exogenous [(14)C]-triolein load, decreasing the incorporation of lipid into adipose tissue and significantly increasing the total (14)CO(2) formation from [(14)C]-triolein. Skeletal muscle and possibly liver seem to be the main organs involved in the action of IL-15 on lipid oxidation, since the presence of the cytokine in incubated EDL muscle with [(14)C]-palmitic acid increased (14)CO(2) formation by 39%. Concerning the mechanism, the results suggest that the transport of fatty acids into mitochondria could be involved in the action of IL-15 since the cytokine clearly increases the presence of L-CPT-I and CPT-II in liver tissue. In addition, IL-15 treatment resulted in a significant increment in the gene expression of PPARdelta, a transcription factor clearly related with lipid catabolism in many tissues. Altogether, the results presented here suggest that IL-15 alters exogenous lipid partitioning, limiting adipose tissue uptake and favouring oxidation.
Vanessa Almendro; Sílvia Busquets; Elisabet Ametller; Neus Carbó; Maite Figueras; Gemma Fuster; Josep M Argilés; Francisco J López-Soriano
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-18
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1761     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-03-13     Completed Date:  2006-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
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MeSH Terms
Interleukin-15 / genetics,  pharmacology*
Organ Specificity
Peroxisome Proliferator-Activated Receptors / genetics
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Triolein / metabolism*
Reg. No./Substance:
0/Interleukin-15; 0/Peroxisome Proliferator-Activated Receptors; 122-32-7/Triolein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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