| Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosis. | |
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MedLine Citation:
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PMID: 19766328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of treatment of multiple sclerosis patients with IFN-beta on elements in the innate and adaptive immune response were analysed in a longitudinal study. We demonstrate significant decreases in anti-Envelope antibody reactivity for the two closely related Gammaretroviral human endogenous retroviruses (HERVs), HERV-H and HERV-W, as a consequence of IFN-beta therapy, closely linked to efficacy of therapy/low disease activity. We also show strong indications of a protective effect of high levels of two components in the innate pathogen-associated molecular pattern recognition: mannan-binding lectin (MBL), and MBL-associated serine protease 3 (MASP-3). Serum levels of typical Th1- and Th2-related, MS-relevant cytokines were also monitored. Overall both Th1- and Th2-associated cytokines were modestly, albeit significantly up-regulated, notably IL-2 and TNF-alpha (MS patients with inactive disease), as well as IL-4 and, to some extent IL-10 (no increase in IL-10 for MS patients with active disease (non-responders)). We found no overall changes in Th1/Th2 ratios. Our results support that HERV-H/HERV-W and the antiviral immune response may play a role in MS development, and that these HERVs have potential as biomarkers for disease activity. |
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Authors:
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Thor Petersen; Anné Møller-Larsen; Steffen Thiel; Tomasz Brudek; Troels Krarup Hansen; Tove Christensen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-18 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 215 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-13 Completed Date: 2009-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 108-16 Citation Subset: IM |
Affiliation:
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Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Complement Pathway, Mannose-Binding Lectin / immunology* Cytokines / biosynthesis*, blood Endogenous Retroviruses / immunology* Female Follow-Up Studies Humans Immunity, Innate / immunology* Interferon-beta / therapeutic use* Male Middle Aged Multiple Sclerosis / blood, immunology*, therapy* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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