Document Detail


Effects of interferon-beta therapy on innate and adaptive immune responses to the human endogenous retroviruses HERV-H and HERV-W, cytokine production, and the lectin complement activation pathway in multiple sclerosis.
MedLine Citation:
PMID:  19766328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of treatment of multiple sclerosis patients with IFN-beta on elements in the innate and adaptive immune response were analysed in a longitudinal study. We demonstrate significant decreases in anti-Envelope antibody reactivity for the two closely related Gammaretroviral human endogenous retroviruses (HERVs), HERV-H and HERV-W, as a consequence of IFN-beta therapy, closely linked to efficacy of therapy/low disease activity. We also show strong indications of a protective effect of high levels of two components in the innate pathogen-associated molecular pattern recognition: mannan-binding lectin (MBL), and MBL-associated serine protease 3 (MASP-3). Serum levels of typical Th1- and Th2-related, MS-relevant cytokines were also monitored. Overall both Th1- and Th2-associated cytokines were modestly, albeit significantly up-regulated, notably IL-2 and TNF-alpha (MS patients with inactive disease), as well as IL-4 and, to some extent IL-10 (no increase in IL-10 for MS patients with active disease (non-responders)). We found no overall changes in Th1/Th2 ratios. Our results support that HERV-H/HERV-W and the antiviral immune response may play a role in MS development, and that these HERVs have potential as biomarkers for disease activity.
Authors:
Thor Petersen; Anné Møller-Larsen; Steffen Thiel; Tomasz Brudek; Troels Krarup Hansen; Tove Christensen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-18
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  215     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-13     Completed Date:  2009-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  108-16     Citation Subset:  IM    
Affiliation:
Department of Neurology, Aarhus University Hospital, Nørrebrogade 44, DK-8000 Aarhus C, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Complement Pathway, Mannose-Binding Lectin / immunology*
Cytokines / biosynthesis*,  blood
Endogenous Retroviruses / immunology*
Female
Follow-Up Studies
Humans
Immunity, Innate / immunology*
Interferon-beta / therapeutic use*
Male
Middle Aged
Multiple Sclerosis / blood,  immunology*,  therapy*
Young Adult
Chemical
Reg. No./Substance:
0/Cytokines; 77238-31-4/Interferon-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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