| Effects of interferon beta-1b on black holes in multiple sclerosis over a 6-year period with monthly evaluations. | |
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MedLine Citation:
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PMID: 16157739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic, hypointense black holes (BHs) are recognized as a sign of permanent damage in patients with multiple sclerosis. Although the effects of interferon beta-1b in reducing the formation of new BHs are established, it is not clear whether the drug may reduce BH duration after these lesions are formed. OBJECTIVE: To analyze the effects of interferon beta-1b in reducing the duration of T1 BHs in patients with multiple sclerosis. DESIGN: Patients were clinically assessed and imaged monthly over a 36-month natural history phase and 36-month therapy phase. Numbers of contrast-enhanced lesions and newly formed BHs were counted on each scan. Each BH was counted until it was no longer seen. SETTING: Outpatient service of the Neuroimmunology Branch at the National Institutes of Health, Bethesda, Md. PATIENTS: Six patients with relapsing-remitting multiple sclerosis were included. One patient did not form any BHs during the therapy phase. Analyses were performed on the remaining 5 individuals. INTERVENTIONS: Interferon beta-1b at the dosage of 8 million international units every other day. MAIN OUTCOME MEASURES: Number and duration (in months) of newly formed BHs. RESULTS: Rate of BH accumulation decreased with treatment (P = .01), but Kaplan-Meier models revealed that the duration of BHs did not shorten (chi2(1) = 2.47, P = .12). CONCLUSIONS: Interferon beta-1b reduces the frequency of new BH formation but does not appear to decrease their duration in time. Analyses with larger patient cohorts are needed to confirm these preliminary findings. |
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Authors:
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Francesca Bagnato; Shiva Gupta; Nancy D Richert; Roger D Stone; Joan M Ohayon; Joseph A Frank; Henry F McFarland |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article Date: 2005-09-12 |
Journal Detail:
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Title: Archives of neurology Volume: 62 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-15 Completed Date: 2005-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1684-8 Citation Subset: AIM; IM |
Affiliation:
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Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1400, USA. bagnatof@ninds.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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therapeutic use* Adult Brain / drug effects*, pathology* Chi-Square Distribution Humans Interferon-beta / therapeutic use* Longitudinal Studies Magnetic Resonance Imaging / methods Multiple Sclerosis / drug therapy*, pathology* Retrospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 145155-23-3/interferon beta-1b; 77238-31-4/Interferon-beta |
| Comments/Corrections | |
Comment In:
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Arch Neurol. 2005 Nov;62(11):1666-8
[PMID:
16286537
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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