Document Detail


Effects of interferon beta-1b on black holes in multiple sclerosis over a 6-year period with monthly evaluations.
MedLine Citation:
PMID:  16157739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic, hypointense black holes (BHs) are recognized as a sign of permanent damage in patients with multiple sclerosis. Although the effects of interferon beta-1b in reducing the formation of new BHs are established, it is not clear whether the drug may reduce BH duration after these lesions are formed. OBJECTIVE: To analyze the effects of interferon beta-1b in reducing the duration of T1 BHs in patients with multiple sclerosis. DESIGN: Patients were clinically assessed and imaged monthly over a 36-month natural history phase and 36-month therapy phase. Numbers of contrast-enhanced lesions and newly formed BHs were counted on each scan. Each BH was counted until it was no longer seen. SETTING: Outpatient service of the Neuroimmunology Branch at the National Institutes of Health, Bethesda, Md. PATIENTS: Six patients with relapsing-remitting multiple sclerosis were included. One patient did not form any BHs during the therapy phase. Analyses were performed on the remaining 5 individuals. INTERVENTIONS: Interferon beta-1b at the dosage of 8 million international units every other day. MAIN OUTCOME MEASURES: Number and duration (in months) of newly formed BHs. RESULTS: Rate of BH accumulation decreased with treatment (P = .01), but Kaplan-Meier models revealed that the duration of BHs did not shorten (chi2(1) = 2.47, P = .12). CONCLUSIONS: Interferon beta-1b reduces the frequency of new BH formation but does not appear to decrease their duration in time. Analyses with larger patient cohorts are needed to confirm these preliminary findings.
Authors:
Francesca Bagnato; Shiva Gupta; Nancy D Richert; Roger D Stone; Joan M Ohayon; Joseph A Frank; Henry F McFarland
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2005-09-12
Journal Detail:
Title:  Archives of neurology     Volume:  62     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-15     Completed Date:  2005-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1684-8     Citation Subset:  AIM; IM    
Affiliation:
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1400, USA. bagnatof@ninds.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / therapeutic use*
Adult
Brain / drug effects*,  pathology*
Chi-Square Distribution
Humans
Interferon-beta / therapeutic use*
Longitudinal Studies
Magnetic Resonance Imaging / methods
Multiple Sclerosis / drug therapy*,  pathology*
Retrospective Studies
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 145155-23-3/interferon beta-1b; 77238-31-4/Interferon-beta
Comments/Corrections
Comment In:
Arch Neurol. 2005 Nov;62(11):1666-8   [PMID:  16286537 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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