| Effects of intensive glycemic control on serum levels of Insulin-like growth factor-I and dehydroepiandrosterone sulfate in type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 21997284 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Although accumulating evidence shows that aging hormones are involved in glucose metabolism, effects of glycemic control on serum insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone-sulfate (DHEA-S) levels are still unclear. Objective and Methods: To investigate the effects of glycemic control on these hormone levels, we conducted a one-month longitudinal study of 49 Japanese patients with type 2 diabetes mellitus. We measured serum levels of IGF-I and DHEA-S before and after one-month glycemic control and analyzed the association of changes in IGF-I and DHEA-S with HbA1c. Results: HbA1c was decreased at one month with mean changes of -1.2 % (p<0.001). Serum IGF-I was increased with mean changes of 11 ng/mL (p<0.05), while serum DHEA-S was decreased with mean changes of -19 μg/dL (p<0.05). Multiple regression analysis showed that changes in DHEA-S were inversely associated with changes in FPG (β=-0.36, p=0.027) and HbA1c (β=-0.33, p=0.028), while changes in IGF-I were not. Conclusion: Present longitudinal study showed that intensive glycemic control for one month increased serum IGF-I level and decreased serum DHEA-S level in Japanese patients with poorly controlled type 2 diabetes. Further studies are needed to clarify the hormonal changes in IGF-I and DHEA-S after intensive glycemic control would affect diabetic complications. |
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Authors:
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Ippei Kanazawa; Toru Yamaguchi; Toshitsugu Sugimoto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-10 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693-8501, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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