Document Detail


Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats.
MedLine Citation:
PMID:  9843555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
These studies determined whether increases in rates of protein synthesis observed in skeletal muscle after moderate or severe acute-resistance exercise were blunted by insulinopenia. Rats (n = 6-9 per group) were made insulin deficient by partial pancreatectomy or remained nondiabetic. Groups either remained sedentary or performed acute-resistance exercise 16 h before rates of protein synthesis were measured in vivo. Exercise required 50 repetitions of standing on the hindlimbs with either 0.6 g backpack wt/g body wt (moderate exercise) or 1.0 g backpack wt/g body wt (severe exercise). Insulin-deficient rats had a mean blood glucose concentration >15 mM and reduced insulin concentrations in the plasma. Rates of protein synthesis in gastrocnemius muscle were not different in all sedentary groups. The moderate-exercised nondiabetic group (192 +/- 12 nmol phenylalanine incorporated. g muscle-1. h-1) and moderate-exercised diabetic group (215 +/- 18) had significantly (P < 0.05, ANOVA) higher rates of protein synthesis than did respective sedentary groups. In contrast, diabetic rats that performed severe-resistance exercise had rates of protein synthesis (176 +/- 12) that were not different (P > 0.05) from diabetic sedentary rats (170 +/- 9), whereas nondiabetic rats that performed severe exercise had higher (212 +/- 24) rates compared with nondiabetic sedentary rats (178 +/- 10) P < 0.05. The present data in combination with previous studies [J. D. Fluckey, T. C. Vary, L. S. Jefferson, and P. A. Farrell. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E313-E319, 1996] show that the amount of insulin required for an in vivo permissive effect of insulin on rates of protein synthesis can be quite low after moderate-intensity resistance exercise. However, severe exercise in combination with low insulin concentrations can ablate an anabolic response.
Authors:
P A Farrell; M J Fedele; T C Vary; S R Kimball; L S Jefferson
Related Documents :
2834215 - Protein synthesis and cyclic gmp content in rat cardiac muscle after swimming exercise.
2943075 - Stereology of myocardial hypertrophy induced by physical exercise.
22818625 - Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging ...
11110995 - Exercise influences spatial learning in the radial arm maze.
3096945 - Pulmonary gas exchange in humans during normobaric hypoxic exercise.
2172175 - Effect of fructose 1,6-diphosphate on exercise capacity in patients with peripheral vas...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  85     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-02-01     Completed Date:  1999-02-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2291-7     Citation Subset:  IM; S    
Affiliation:
Noll Physiological Research Center and Department of Kinesiology, University Park 16802, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Experimental / blood,  metabolism*,  physiopathology
Insulin / blood
Kinetics
Male
Muscle Proteins / biosynthesis*
Muscle, Skeletal / metabolism*,  physiopathology
Pancreatectomy
Physical Exertion / physiology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
AR-43127/AR/NIAMS NIH HHS; DK-15658/DK/NIDDK NIH HHS; GM-39277/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Insulin; 0/Muscle Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanical advantage of the canine diaphragm.
Next Document:  Mechanism of pyocyanin- and 1-hydroxyphenazine-induced lung neutrophilia in sheep airways.