| Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats. | |
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MedLine Citation:
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PMID: 9843555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These studies determined whether increases in rates of protein synthesis observed in skeletal muscle after moderate or severe acute-resistance exercise were blunted by insulinopenia. Rats (n = 6-9 per group) were made insulin deficient by partial pancreatectomy or remained nondiabetic. Groups either remained sedentary or performed acute-resistance exercise 16 h before rates of protein synthesis were measured in vivo. Exercise required 50 repetitions of standing on the hindlimbs with either 0.6 g backpack wt/g body wt (moderate exercise) or 1.0 g backpack wt/g body wt (severe exercise). Insulin-deficient rats had a mean blood glucose concentration >15 mM and reduced insulin concentrations in the plasma. Rates of protein synthesis in gastrocnemius muscle were not different in all sedentary groups. The moderate-exercised nondiabetic group (192 +/- 12 nmol phenylalanine incorporated. g muscle-1. h-1) and moderate-exercised diabetic group (215 +/- 18) had significantly (P < 0.05, ANOVA) higher rates of protein synthesis than did respective sedentary groups. In contrast, diabetic rats that performed severe-resistance exercise had rates of protein synthesis (176 +/- 12) that were not different (P > 0.05) from diabetic sedentary rats (170 +/- 9), whereas nondiabetic rats that performed severe exercise had higher (212 +/- 24) rates compared with nondiabetic sedentary rats (178 +/- 10) P < 0.05. The present data in combination with previous studies [J. D. Fluckey, T. C. Vary, L. S. Jefferson, and P. A. Farrell. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E313-E319, 1996] show that the amount of insulin required for an in vivo permissive effect of insulin on rates of protein synthesis can be quite low after moderate-intensity resistance exercise. However, severe exercise in combination with low insulin concentrations can ablate an anabolic response. |
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Authors:
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P A Farrell; M J Fedele; T C Vary; S R Kimball; L S Jefferson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 85 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-02-01 Completed Date: 1999-02-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2291-7 Citation Subset: IM; S |
Affiliation:
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Noll Physiological Research Center and Department of Kinesiology, University Park 16802, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Experimental / blood, metabolism*, physiopathology Insulin / blood Kinetics Male Muscle Proteins / biosynthesis* Muscle, Skeletal / metabolism*, physiopathology Pancreatectomy Physical Exertion / physiology* Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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AR-43127/AR/NIAMS NIH HHS; DK-15658/DK/NIDDK NIH HHS; GM-39277/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Muscle Proteins; 11061-68-0/Insulin |
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