Document Detail

Effects of intense tone exposure on choline acetyltransferase activity in the hamster cochlear nucleus.
MedLine Citation:
PMID:  16549284     Owner:  NLM     Status:  MEDLINE    
Choline acetyltransferase (ChAT) activity has been mapped in the cochlear nucleus (CN) of control hamsters and hamsters that had been exposed to an intense tone. ChAT activity in most CN regions of hamsters was only a third or less of the activity in rat CN, but in granular regions ChAT activity was similar in both species. Eight days after intense tone exposure, average ChAT activity increased on the tone-exposed side as compared to the opposite side, by 74% in the anteroventral CN (AVCN), by 55% in the granular region dorsolateral to it, and by 74% in the deep layer of the dorsal CN (DCN). In addition, average ChAT activity in the exposed-side AVCN and fusiform soma layer of DCN was higher than in controls, by 152% and 67%, respectively. Two months after exposure, average ChAT activity was still 53% higher in the exposed-side deep layer of DCN as compared to the opposite side. Increased ChAT activity after intense tone exposure may indicate that this exposure leads to plasticity of descending cholinergic innervation to the CN, which might affect spontaneous activity in the DCN that has been associated with tinnitus.
Yong-Ming Jin; Donald A Godfrey; Jie Wang; James A Kaltenbach
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-03-23
Journal Detail:
Title:  Hearing research     Volume:  216-217     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:    2006 Jun-Jul
Date Detail:
Created Date:  2006-06-19     Completed Date:  2007-06-21     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  168-75     Citation Subset:  IM    
Division of Otolaryngology, Department of Surgery, Medical University of Ohio, Toledo, 3065 Arlington Avenue, OH 43614-5807, USA.
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MeSH Terms
Analysis of Variance
Auditory Threshold / physiology
Choline O-Acetyltransferase / metabolism*
Cochlear Nucleus / enzymology*,  physiopathology
Hearing Loss, Noise-Induced / enzymology,  physiopathology*
Neuronal Plasticity / physiology
Noise / adverse effects*
Grant Support
Reg. No./Substance:
EC O-Acetyltransferase

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