Document Detail

Effects of intense exercise in chronic spinal cord injury.
MedLine Citation:
PMID:  18521094     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exercise has beneficial effects on muscle and motor function after spinal cord injury (SCI). Little is known regarding effects of prolonged intense exercise (IE) in humans with chronic SCI.
DESIGN: Prospective, non-randomized, controlled observational study. The intervention was either a multimodal IE program (n=21) or a control (CTL) intervention consisting of self-regulated exercise (n=8).
OBJECTIVE: Measure sensorimotor function over 6 months in relation to an IE program.
SETTING: Single outpatient center.
SUBJECTS: Subjects with chronic SCI (n=29 total), mainly ASIA Impairment Scale A and B, injury levels C4-T11.
RESULTS: Baseline neurological assessments (for example, ASIA motor score, 39+/-3 vs 42+/-5, IE vs CTL, P>0.5, mean+/-s.e.m.) did not differ between the two groups. During the 6 months, IE subjects averaged 7.3+/-0.7 h per week exercise, not significantly different from CTL subjects (5.2+/-1.3 h per week, P>0.1). However, after 6 months, IE subjects showed significantly greater motor gains than CTL subjects in the main outcome measure, ASIA motor score (change of 4.8+/-1.0 vs -0.1+/-0.5 points, P=0.0001). The main outcome measure was calculated by ASIA motor score. These IE subject ASIA motor gains correlated with number of exercise hours per week (r=0.53, P<0.02), and with type of specific IE components, particularly load bearing.
CONCLUSIONS: Multimodal IE can significantly improve motor function in subjects with chronic SCI. An organized program may provide greater motor benefits than a self-regulated program; load bearing might be of particular value. IE might have therapeutic value in chronic SCI, and as an adjunct to other restorative therapies.
E T Harness; N Yozbatiran; S C Cramer
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-06-03
Journal Detail:
Title:  Spinal cord     Volume:  46     ISSN:  1362-4393     ISO Abbreviation:  Spinal Cord     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-06     Completed Date:  2009-01-12     Revised Date:  2011-06-06    
Medline Journal Info:
Nlm Unique ID:  9609749     Medline TA:  Spinal Cord     Country:  England    
Other Details:
Languages:  eng     Pagination:  733-7     Citation Subset:  IM    
Project Walk Spinal Cord Injury Recovery, Department of Research and Development, Carlsbad, CA, USA.
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MeSH Terms
Chronic Disease
Disability Evaluation
Ergometry / methods
Exercise / physiology*
Neurologic Examination / methods
Prospective Studies
Psychomotor Performance / physiology*
Recovery of Function / physiology*
Spinal Cord Injuries / physiopathology,  rehabilitation*
Trauma Severity Indices
Treatment Outcome
Weight-Bearing / physiology
Grant Support
5M011 RR-00827-29/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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