Document Detail


Effects of insulin-like growth factor I (IGF-I) on the porto-arterial concentration differences of amino acids and glucose: a comparison between oral and intraperitoneal administration in the newborn piglet.
MedLine Citation:
PMID:  8960897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is established that insulin-like growth factor I (IGF-I) influences cell differentiation and proliferation. Less is known, however, if such changes also influence the flow of nutrients from the intestinal lumen to the portal circulation. In the present study, we tested if IGF-I treatment (0.3 mg IGF-I/24 hr and kg) during 7 days affects the porto-arterial concentration differences of amino acids and glucose in piglets. Two routes of administration, oral and intraperitoneal, were compared. Following the IGF-I treatment, a bolus of nutrients was administered to the proximal duodenum and the porto-arterial concentration differences of amino acids and glucose were determined. We found that intraperitoneal administration of IGF-I significantly increased the difference in concentration between portal and arterial plasma for amino acids, whereas no such effect was seen with glucose. This might suggest that IGF-I has a specific effect on amino acid transporters in the intestinal wall. The same dose of IGF-I given orally did not exhibit the same effect on the absorption of amino acid as the animals which were given the peptide intraperitoneally.
Authors:
K Fhölenhog; K Malmlöf; H Saxerholt; G Klingström; A Skottner; F Nyberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  28     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  582-7     Citation Subset:  IM    
Affiliation:
Pharmacia & Upjohn, Research, Department of Pharmacology, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Amino Acids / blood*
Animals
Animals, Newborn*
Blood Glucose / metabolism*
Carotid Arteries*
Humans
Injections, Intraperitoneal
Insulin / blood
Insulin-Like Growth Factor I / administration & dosage,  metabolism,  pharmacology*
Male
Portal Vein*
Swine
Weight Gain
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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