Document Detail

Effects of insulin-like growth factor-I on the expression of osteoclasts and osteoblasts in the nasopremaxillary suture under different masticatory loading conditions in growing mice.
MedLine Citation:
PMID:  12615139     Owner:  NLM     Status:  MEDLINE    
It is well accepted that mechanical loading inhibits bone resorption and increases in vivo bone formation. It is also known that cyclic mechanical loading, in particular, can enhance bone formation significantly. These findings suggest a significant role for mechanical stimuli in bone remodelling mediated by various local growth factors including insulin-like growth factor-I (IGF-I). Earlier studies showed that the nasal bone length and premaxillary bone width were significantly greater in mice fed a solid diet rather than a granulated diet, and that these dimensions increased significantly in a solid-diet group treated with IGF-I. The present study sought to examine the effect of IGF-I on the expression of osteoclasts and osteoblasts in the nasopremaxillary suture subjected to different masticatory loadings. For the solid-diet groups, the numbers of tartrate-resistant acid phosphatase (TRAP)-positive osteoclastic cells and osteoblasts were significantly greater in the group injected with IGF-I than in the animals injected with physiological saline. In the groups fed a granulated diet, no significant differences in the numbers of TRAP-positive osteoclastic cells and osteoblasts were found over the entire experimental period between mice injected with either IGF-I or physiological saline. It is shown that IGF-I significantly induces the expression of osteoclasts and osteoblasts and the subsequent bone remodelling, and that the effect may be additive as compared to that of mechanical masticatory loading, which seems to be more important in bone remodelling in terms of the numbers of osteoclasts and osteoblasts.
C Tokimasa; T Kawata; T Fujita; M Kaku; S Kohno; K Tsutsui; K Tenjou; J Ohtani; M Motokawa; K Tanne
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  48     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-04     Completed Date:  2003-06-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  D; IM    
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minamiku, 734-8553, Hiroshima, Japan.
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MeSH Terms
Acid Phosphatase / metabolism
Body Weight
Bone Remodeling / drug effects,  physiology
Insulin-Like Growth Factor I / pharmacology*
Isoenzymes / metabolism
Mastication / physiology*
Maxilla / cytology,  drug effects,  enzymology
Mice, Inbred C57BL
Nose / cytology,  drug effects,  enzymology
Osteoblasts / drug effects*,  enzymology
Osteoclasts / drug effects*,  enzymology
Stress, Mechanical
Reg. No./Substance:
0/Isoenzymes; 67763-96-6/Insulin-Like Growth Factor I; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC Phosphatase

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