Document Detail


Effects of insulin-like growth factor-I on the expression of osteoclasts and osteoblasts in the nasopremaxillary suture under different masticatory loading conditions in growing mice.
MedLine Citation:
PMID:  12615139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well accepted that mechanical loading inhibits bone resorption and increases in vivo bone formation. It is also known that cyclic mechanical loading, in particular, can enhance bone formation significantly. These findings suggest a significant role for mechanical stimuli in bone remodelling mediated by various local growth factors including insulin-like growth factor-I (IGF-I). Earlier studies showed that the nasal bone length and premaxillary bone width were significantly greater in mice fed a solid diet rather than a granulated diet, and that these dimensions increased significantly in a solid-diet group treated with IGF-I. The present study sought to examine the effect of IGF-I on the expression of osteoclasts and osteoblasts in the nasopremaxillary suture subjected to different masticatory loadings. For the solid-diet groups, the numbers of tartrate-resistant acid phosphatase (TRAP)-positive osteoclastic cells and osteoblasts were significantly greater in the group injected with IGF-I than in the animals injected with physiological saline. In the groups fed a granulated diet, no significant differences in the numbers of TRAP-positive osteoclastic cells and osteoblasts were found over the entire experimental period between mice injected with either IGF-I or physiological saline. It is shown that IGF-I significantly induces the expression of osteoclasts and osteoblasts and the subsequent bone remodelling, and that the effect may be additive as compared to that of mechanical masticatory loading, which seems to be more important in bone remodelling in terms of the numbers of osteoclasts and osteoblasts.
Authors:
C Tokimasa; T Kawata; T Fujita; M Kaku; S Kohno; K Tsutsui; K Tenjou; J Ohtani; M Motokawa; K Tanne
Related Documents :
20174979 - Association of increased hair calcium levels and enhanced augmentation index (aix): a m...
2720199 - Adverse effects of a high-glucose diet on body weight and plasma calcium and 1,25-dihyd...
21535859 - The effect of a flaxseed oil-enhanced diet on the product quality of farmed brook trout...
6864339 - Dietary nacl loads promote calciuria and bone loss in adult oophorectomized rats consum...
14580369 - Prostacyclin and thromboxane a2 production in nitric oxide-deficient hypertension in vi...
504689 - A calcitonin-like action of prostaglandin e1.
17521119 - Methods for using nutrient intake values (nivs) to assess or plan nutrient intakes.
23378299 - Mild renal dysfunction and metabolites tied to low hdl cholesterol are associated with ...
2767879 - Changes in intraventricular septal thickness, left ventrical wall thickness and left ve...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of oral biology     Volume:  48     ISSN:  0003-9969     ISO Abbreviation:  Arch. Oral Biol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-04     Completed Date:  2003-06-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0116711     Medline TA:  Arch Oral Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  D; IM    
Affiliation:
Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Faculty of Dentistry, Hiroshima University, 1-2-3 Kasumi, Minamiku, 734-8553, Hiroshima, Japan. tokichi@hiroshima-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / metabolism
Animals
Body Weight
Bone Remodeling / drug effects,  physiology
Diet
Insulin-Like Growth Factor I / pharmacology*
Isoenzymes / metabolism
Mastication / physiology*
Maxilla / cytology,  drug effects,  enzymology
Mice
Mice, Inbred C57BL
Nose / cytology,  drug effects,  enzymology
Osteoblasts / drug effects*,  enzymology
Osteoclasts / drug effects*,  enzymology
Stress, Mechanical
Chemical
Reg. No./Substance:
0/Isoenzymes; 67763-96-6/Insulin-Like Growth Factor I; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Copper ions inhibit the demineralisation of human enamel.
Next Document:  The influence of fluoride on the cellular morphology and synthetic activity of the rat dentine-pulp ...