| Effects of insulin and glucagon on serum amino acid concentrations in liver disease. | |
MedLine Citation:
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PMID: 6760674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of insulin and glucagon administration on serum amino acid levels were investigated in patients with severe liver disease, since simultaneous injection of pancreatic hormones has been recently introduced as a therapeutic approach. The changes in serum amino acid concentrations, as observed 3 h after ceasing a 3 h infusion of insulin and glucagon in 500 ml glucose solution, were an elevation of serum branched chain amino acid (BACA) levels and of the molar ratio of BCAA/aromatic amino acid (AAA) levels in patients with liver cirrhosis. Similar increases of serum BCAA levels during the infusion were also observed in patients with fulminant hepatitis. The results suggest that insulin-glucagon therapy for severe liver disease has no harmful side effects at least with respect to alterations in the serum aminogram. |
Authors:
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A Watanabe; T Higashi; S Hayashi; T Obata; T Sakata; N Takei; T Shiota; H Nagashima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Okayama Volume: 36 ISSN: 0386-300X ISO Abbreviation: Acta Med. Okayama Publication Date: 1982 Dec |
Date Detail:
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Created Date: 1983-03-17 Completed Date: 1983-03-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417611 Medline TA: Acta Med Okayama Country: JAPAN |
Other Details:
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Languages: eng Pagination: 441-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood* Amino Acids, Branched-Chain / blood Drug Therapy, Combination Glucagon / administration & dosage*, blood, therapeutic use Hepatitis / blood, drug therapy* Humans Infusions, Parenteral Insulin / administration & dosage*, blood, therapeutic use Liver Cirrhosis / blood, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Branched-Chain; 11061-68-0/Insulin; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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