Document Detail

Effects of insulin and glucagon on serum amino acid concentrations in liver disease.
MedLine Citation:
PMID:  6760674     Owner:  NLM     Status:  MEDLINE    
The effects of insulin and glucagon administration on serum amino acid levels were investigated in patients with severe liver disease, since simultaneous injection of pancreatic hormones has been recently introduced as a therapeutic approach. The changes in serum amino acid concentrations, as observed 3 h after ceasing a 3 h infusion of insulin and glucagon in 500 ml glucose solution, were an elevation of serum branched chain amino acid (BACA) levels and of the molar ratio of BCAA/aromatic amino acid (AAA) levels in patients with liver cirrhosis. Similar increases of serum BCAA levels during the infusion were also observed in patients with fulminant hepatitis. The results suggest that insulin-glucagon therapy for severe liver disease has no harmful side effects at least with respect to alterations in the serum aminogram.
A Watanabe; T Higashi; S Hayashi; T Obata; T Sakata; N Takei; T Shiota; H Nagashima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Okayama     Volume:  36     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-03-17     Completed Date:  1983-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
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MeSH Terms
Amino Acids / blood*
Amino Acids, Branched-Chain / blood
Drug Therapy, Combination
Glucagon / administration & dosage*,  blood,  therapeutic use
Hepatitis / blood,  drug therapy*
Infusions, Parenteral
Insulin / administration & dosage*,  blood,  therapeutic use
Liver Cirrhosis / blood,  drug therapy*
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain; 11061-68-0/Insulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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