| Effects of insulin and acarbose alone and in combination in the female streptozotocin-induced diabetic rat. | |
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MedLine Citation:
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PMID: 8308697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetes is characterized by hyperphagia, polydipsia, polyuria, elevations in blood and urinary glucose, and alterations in the adrenergic nervous system. Insulin treatment is effective in reversing most of the adverse conditions of diabetes in the streptozotocin-treated rat. Acarbose (BAY G 5421), an intestinal alpha-glucosidase inhibitor, decreases postprandial glycemia by delaying carbohydrate absorption and also affords some beneficial effects in the diabetic animal. The purpose of this study was to evaluate the effects of chronic insulin (< or = 2 U/day) with and without acarbose treatment (20 mg/100 g of diet) on the metabolic and adrenergic parameters altered in streptozotocin (50 mg/kg, intravenously)-induced diabetes in female rats. Insulin dosage was changed weekly after the first 2 weeks of treatment in both insulin-treated groups in an attempt to maintain a level of blood glucose that was comparable to that achieved with acarbose treatment alone. Insulin dosage was reduced to a greater extent in the dual-treated group than in the group treated with insulin alone. Diabetic rats were hyperphagic, polydipsic, and polyuric within 1 week of streptozotocin treatment. Each treatment alone was effective in reducing these alterations. However, these reductions were more apparent in the combined therapy group. Only in this combined therapy group was glycated hemoglobin returned to normal. All treatments also prevented the significant weight loss observed in untreated diabetic animals. Adrenergic responses were assessed by monitoring the rise in tail skin temperature associated with administration of isoproterenol. Diabetic rats were less responsive than controls, and each of the treatments restored this response.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M J Katovich; M J Meldrum |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 82 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-16 Completed Date: 1994-03-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1209-13 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, College of Pharmacy, University of Florida, JHMHC, Gainesville 32610. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acarbose Animals Blood Glucose / drug effects, metabolism Body Weight / drug effects Diabetes Mellitus, Experimental / blood, drug therapy*, urine Disease Models, Animal Drinking / drug effects Drug Therapy, Combination Eating / drug effects Female Glycosuria / urine Hyperglycemia / blood, drug therapy Hypoglycemic Agents / pharmacology* Insulin / pharmacology* Rats Rats, Sprague-Dawley Temperature Trisaccharides / pharmacology* Urodynamics / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HD 18133/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Trisaccharides; 11061-68-0/Insulin; 56180-94-0/Acarbose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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