Document Detail


Effects of instrumental dead space reduction during weaning from synchronized ventilation in preterm infants.
MedLine Citation:
PMID:  20010615     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: A majority of the modalities of synchronized ventilation in preterm infants require the use of flow sensors that can increase dead space and may adversely affect ventilator weaning. The objective of this study was to assess the effects of flow sensor dead space during synchronized intermittent mandatory ventilation (SIMV) weaning in preterm infants. STUDY DESIGN: Twelve preterm infants (gestational age 25+/-2 weeks, birth weight 705+/-158 g, age: 31+/-186 days, SIMV rate: 25+/-8 breaths min(-1), peak inspiratory pressure 18+/-2 cm H(2)O, positive end-expiratory pressure: 5+/-0.5 cm H(2)O, pressure support: 9+/-3 cm H(2)O, fraction of inspired oxygen: 34+/-6%) underwent two 2.5-h weaning periods during which SIMV rate was reduced twice by 5 breaths min(-1) at 30-min intervals as tolerated, with and without reduction of flow sensor dead space, in random sequence. A 30-min baseline was obtained before each weaning period. Dead space was reduced by flushing the flow sensor with a continuous gas leak flow in the endotracheal tube connector. RESULT: Transcutaneous CO(2) tension during SIMV weaning periods without and with reduced dead space did not differ from baseline, whereas total minute ventilation and tidal volume were lower during the SIMV weaning period with reduced dead space. Three infants did not tolerate SIMV weaning without while one infant did not tolerate weaning with reduced dead space. CONCLUSION: SIMV weaning elicited a compensatory rise in spontaneous ventilation. When flow sensor dead space was reduced during SIMV weaning, gas exchange was maintained with lower minute ventilation. Instrumental dead space imposes a ventilatory burden during SIMV weaning in small preterm infants.
Authors:
A Estay; N Claure; C D'Ugard; R Organero; E Bancalari
Related Documents :
23906905 - Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth we...
8187025 - Reduced mite allergen levels in dwellings with mechanical exhaust and supply ventilation.
18754825 - Long-term non-invasive positive airway pressure ventilation in infants.
23920315 - Levels of prenatal mercury exposure and their relationships to neonatal anthropometry i...
1052085 - Consultation in the intensive care nursery.
2076965 - Postnatal growth of cochlear spiral in mongolian gerbil.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-10
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-83     Citation Subset:  IM    
Affiliation:
Pontificia Universidad Catolica de Chile, Santiago, Chile.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nurses' compliance with alarm limits for pulse oximetry: qualitative study.
Next Document:  Early cortisol values and long-term outcomes in extremely low birth weight infants.