Document Detail

Effects of instrumental dead space reduction during weaning from synchronized ventilation in preterm infants.
MedLine Citation:
PMID:  20010615     Owner:  NLM     Status:  In-Process    
OBJECTIVE: A majority of the modalities of synchronized ventilation in preterm infants require the use of flow sensors that can increase dead space and may adversely affect ventilator weaning. The objective of this study was to assess the effects of flow sensor dead space during synchronized intermittent mandatory ventilation (SIMV) weaning in preterm infants. STUDY DESIGN: Twelve preterm infants (gestational age 25+/-2 weeks, birth weight 705+/-158 g, age: 31+/-186 days, SIMV rate: 25+/-8 breaths min(-1), peak inspiratory pressure 18+/-2 cm H(2)O, positive end-expiratory pressure: 5+/-0.5 cm H(2)O, pressure support: 9+/-3 cm H(2)O, fraction of inspired oxygen: 34+/-6%) underwent two 2.5-h weaning periods during which SIMV rate was reduced twice by 5 breaths min(-1) at 30-min intervals as tolerated, with and without reduction of flow sensor dead space, in random sequence. A 30-min baseline was obtained before each weaning period. Dead space was reduced by flushing the flow sensor with a continuous gas leak flow in the endotracheal tube connector. RESULT: Transcutaneous CO(2) tension during SIMV weaning periods without and with reduced dead space did not differ from baseline, whereas total minute ventilation and tidal volume were lower during the SIMV weaning period with reduced dead space. Three infants did not tolerate SIMV weaning without while one infant did not tolerate weaning with reduced dead space. CONCLUSION: SIMV weaning elicited a compensatory rise in spontaneous ventilation. When flow sensor dead space was reduced during SIMV weaning, gas exchange was maintained with lower minute ventilation. Instrumental dead space imposes a ventilatory burden during SIMV weaning in small preterm infants.
A Estay; N Claure; C D'Ugard; R Organero; E Bancalari
Related Documents :
22990095 - Innate small babies are metabolically healthy children.
24035985 - Customized large-for-gestational-age birthweight at term and the association with adver...
24933685 - Adjusting to motherhood-the importance of bmi in predicting maternal well-being, eating...
24849035 - Analysis of risk factors for lipid intolerance of intravenous fat emulsion in very low ...
319115 - The relationship of a-b, field dependency, and emotional openness in paranoid and nonpa...
11498485 - Ecological study of effect of breast feeding on infant mortality in latin america.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-10
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  479-83     Citation Subset:  IM    
Pontificia Universidad Catolica de Chile, Santiago, Chile.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nurses' compliance with alarm limits for pulse oximetry: qualitative study.
Next Document:  Early cortisol values and long-term outcomes in extremely low birth weight infants.