Document Detail

Effects of inspiratory impedance on hemodynamic responses to a squat-stand test in human volunteers: implications for treatment of orthostatic hypotension.
MedLine Citation:
PMID:  15864634     Owner:  NLM     Status:  MEDLINE    
Recent studies in our laboratory demonstrated that spontaneous breathing through an inspiratory impedance threshold device (ITD) increased heart rate (HR), stroke volume (SV), cardiac output (Q), and mean arterial blood pressure (MAP) in supine human subjects. In this study, we tested the effectiveness of an ITD as a countermeasure against development of orthostatic hypotension, provoked using a squat-to-stand test (SST). Using a prospective, randomized blinded protocol, 18 healthy, normotensive volunteers (9 males, 9 females) completed two-counterbalanced 6-min SST protocols with and without (sham) an ITD set to open at 0.7 kPa (7-cm H(2)O) pressure. HR, SV, Q, total peripheral resistance (TPR), and MAP were assessed noninvasively with infrared finger photoplethysmography. Symptoms were recorded on a 5-point scale (1 = normal; 5 = faint) of subject perceived rating (SPR). The reduction in TPR produced by SST (-35 +/- 5 %) was not affected by the ITD. Reduction in MAP with ITD during the transient phase of the SST (-3.6 +/- 0.5 kPa or -27 +/- 4 mmHg) was less (P = 0.03) than that measured while breathing through a sham device (-4.8 +/- 0.4 kPa or -36 +/- 3 mmHg) despite similar (P < 0.926) elevations in HR of 15 +/- 2 bpm. SV (+2 +/- 4 %) and Q (+22 +/- 5 %) with the ITD were higher (P < 0.04) than SV (-8 +/- 4 %) and Q (+10 +/- 6 %) without the ITD. SPR was 1.4 +/- 0.1 with ITD compared to 2.0 +/- 0.2 with the sham device (P < 0.04). This reduction in orthostatic symptoms with application of an ITD during the SST was associated with higher MAP, SV and Q. Our results demonstrate the potential application of an ITD as a countermeasure against orthostatic hypotension.
Victor A Convertino; Duane A Ratliff; Jacqueline Crissey; Donald F Doerr; Ahamed H Idris; Keith G Lurie
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-04-28
Journal Detail:
Title:  European journal of applied physiology     Volume:  94     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-27     Completed Date:  2006-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  392-9     Citation Subset:  IM    
US Army Institute of Surgical Research, Fort Sam Houston, TX, 78234-6315, USA.
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MeSH Terms
Blood Pressure
Cardiac Output
Cardiography, Impedance / instrumentation*,  methods
Double-Blind Method
Hypotension, Orthostatic / prevention & control,  therapy*
Prospective Studies

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