Document Detail


Effects of injury discharge on the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat.
MedLine Citation:
PMID:  8402150     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of the peripheral neuroma attenuates this long-term expression of Fos. In addition to the sustained activity of the injured afferents, the nerve transection itself results, acutely, in a massive injury-induced neural discharge. In this study we evaluated the effect of blocking this massive injury discharge on the persistence of Fos expression. Just prior to nerve transection we applied the short-acting local anesthetic, lidocaine, to the sciatic nerve. Control injections were made subcutaneously on the dorsum of the neck. We report that injection of the local anesthetic, by either route, significantly reduced the number of fos-like immunoreactive neurons at 2 days after nerve transection. The effect was only observed on neurons in the superficial dorsal horn. These results indicate that along with sustained activity of injured afferents and of reorganization of central circuits after injury, the initial brief discharge at the time of nerve injury contributes to a prolonged increase in the activity of spinal cord neurons.
Authors:
S I Chi; J D Levine; A I Basbaum
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  617     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-29     Completed Date:  1993-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Affiliation:
Department of Anatomy, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Animals
Immunohistochemistry
Male
Nerve Tissue Proteins / biosynthesis*
Pain / physiopathology*
Proto-Oncogene Proteins c-fos / biosynthesis*
Rats
Rats, Sprague-Dawley
Sciatic Nerve / injuries*
Spinal Cord / metabolism*
Grant Support
ID/Acronym/Agency:
DE/NIDA 08973/DE/NIDCR NIH HHS; NS 14627/NS/NINDS NIH HHS; NS 21445/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Proto-Oncogene Proteins c-fos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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