Document Detail

Effects of inhibition of nitric oxide synthesis in patients with coronary artery disease and stable angina.
MedLine Citation:
PMID:  9129890     Owner:  NLM     Status:  MEDLINE    
AIMS: Inhibition of nitric oxide synthesis causes a decrease in the basal diameter of normal distal epicardial coronary arteries in normal subjects. The effects of inhibition of nitric oxide in atheromatous coronary arteries is unknown. This study assessed the effects of the inhibition of nitric oxide synthesis in epicardial coronary arteries in patients with coronary artery disease. METHODS AND RESULTS: The effects of an intracoronary infusion of NG-monomethyl-L-arginine (LNMMA, an inhibitor of nitric oxide synthesis), were studied in 13 patients with chronic stable angina and coronary artery disease. The diameter of angiographically normal proximal and distal segments and coronary stenoses was measured by quantitative angiography. In response to an LNMMA infusion of 16 mumol min-1 for 4 min there was a significant reduction (P < 0.01) in the luminal diameter of the distal segments of diseased arteries (from 1.32 +/- 0.07 to 1.17 +/- 0.06 mm) and at the site of stenosis (from 1.15 +/- 0.22 to 1.06 +/- 0.20 mm), but no change (P = NS) in the luminal diameter of the proximal segments (from 3.16 +/- 0.12 to 3.08 +/- 0.14 mm) of diseased arteries. CONCLUSIONS: The average effect of inhibition of basal nitric oxide synthesis in epicardial coronary arteries in patients with stable angina and coronary artery disease was only distal constriction. Coronary stenoses constricted at the highest LNMMA concentration.
D Tousoulis; G J Davies; C Tentolouris; T Crake; D C Lefroy; P Toutouzas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  18     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  608-13     Citation Subset:  IM    
Cardiology Units, Hippokration Hospital, Athens University Medical School, Greece.
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MeSH Terms
Angina Pectoris / physiopathology
Coronary Angiography / drug effects
Coronary Artery Disease / physiopathology*
Coronary Circulation / drug effects,  physiology
Dose-Response Relationship, Drug
Electrocardiography / drug effects
Enzyme Inhibitors / pharmacology*
Nitric Oxide / physiology*
Nitric Oxide Synthase / antagonists & inhibitors*,  physiology
Nitroglycerin / pharmacology
Vasoconstriction / drug effects,  physiology
omega-N-Methylarginine / pharmacology*
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 55-63-0/Nitroglycerin; EC Oxide Synthase

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