Document Detail


Effects of inhaled sympathomimetics on obstructive response to respiratory heat loss.
MedLine Citation:
PMID:  7047469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the influence of inhaled sympathomimetics on the obstructive response to airway cooling, we had six asymptomatic atopic asthmatics perform eucapnic hyperventilation with frigid air at various levels of ventilation after pretreatment with aerosols of metaproterenol or placebo in a random blind fashion. In control experiments, eucapnic hyperventilation produced a progressive decrease in 1-s forced expiratory volume in a stimulus-response fashion as the level of ventilation rose in successive challenges. Metaproterenol did not produce an all-or-none blockade, but rather a parallel shift in the stimulus-response curve so that its protective effects could be overcome by increasing the stimulus. There was no effect on respiratory heat loss. These results explain, in a quantitative fashion, why a treatment schedule that permits a person with asthma to perform a given exercise task without difficulty becomes ineffective as the thermal burden or severity of the task increases.
Authors:
T H Rossing; J W Weiss; F J Breslin; R H Ingram; E R McFadden
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  52     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1119-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aerosols
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy*,  physiopathology
Body Temperature Regulation*
Clinical Trials as Topic
Female
Forced Expiratory Volume
Humans
Male
Respiration
Respiratory System / physiopathology*
Sympathomimetics / administration & dosage,  therapeutic use*
Grant Support
ID/Acronym/Agency:
HL-17382/HL/NHLBI NIH HHS; HL-17873/HL/NHLBI NIH HHS; HL-19170/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aerosols; 0/Sympathomimetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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