Document Detail

Effects of inhaled sympathomimetics on obstructive response to respiratory heat loss.
MedLine Citation:
PMID:  7047469     Owner:  NLM     Status:  MEDLINE    
To investigate the influence of inhaled sympathomimetics on the obstructive response to airway cooling, we had six asymptomatic atopic asthmatics perform eucapnic hyperventilation with frigid air at various levels of ventilation after pretreatment with aerosols of metaproterenol or placebo in a random blind fashion. In control experiments, eucapnic hyperventilation produced a progressive decrease in 1-s forced expiratory volume in a stimulus-response fashion as the level of ventilation rose in successive challenges. Metaproterenol did not produce an all-or-none blockade, but rather a parallel shift in the stimulus-response curve so that its protective effects could be overcome by increasing the stimulus. There was no effect on respiratory heat loss. These results explain, in a quantitative fashion, why a treatment schedule that permits a person with asthma to perform a given exercise task without difficulty becomes ineffective as the thermal burden or severity of the task increases.
T H Rossing; J W Weiss; F J Breslin; R H Ingram; E R McFadden
Related Documents :
16809239 - Role of vascular endothelial growth factor in pulmonary endothelial cell injury by exer...
7453589 - Is airway hyperactivity in asthma due to histamine h2-receptor deficiency?
2778329 - Effect of exercise stress on the bronchospastic response of asthmatics in remission.
2009799 - Increased airways responsiveness in swine farmers.
18036999 - Airway response to induced muscular contraction in spontaneously breathing rabbits.
115619 - Blood histamine levels after exercise testing.
3355239 - Role of dehydration in heat stress-induced variations in mental performance.
12471309 - Exercise and hypoxia: effects on leukocytes and interleukin-6-shared mechanisms?
3728329 - Multistage analysis of exercise radionuclide angiography in coronary artery disease.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  52     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1119-23     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Asthma / drug therapy*
Asthma, Exercise-Induced / drug therapy*,  physiopathology
Body Temperature Regulation*
Clinical Trials as Topic
Forced Expiratory Volume
Respiratory System / physiopathology*
Sympathomimetics / administration & dosage,  therapeutic use*
Grant Support
Reg. No./Substance:
0/Aerosols; 0/Sympathomimetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of limb immobilization on skeletal muscle.
Next Document:  Hemodynamic and vasoactive mediator response to experimental respiratory failure.