| Effects of inhaled salbutamol in exercising non-asthmatic athletes. | |
| | |
MedLine Citation:
|
PMID: 11514686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Beta-2 agonists such as salbutamol are used, not only by asthmatic athletes to prevent exercise induced asthma, but also by non-asthmatic athletes as a potentially ergogenic agent. We have investigated whether inhaled salbutamol enhances endurance performance in non-asthmatic athletes. METHODS: A prospective double blind, randomised, three way crossover design was used to study the effects of 200 microg and 800 microg inhaled salbutamol versus a placebo in 12 trained triathletes. The treatments were compared in three identical cycle ergometer sessions at 85% of the predetermined maximal oxygen uptake. Lung function, endurance time, metabolic parameters (glucose, potassium, lactate, free fatty acid, and glycerol), and psychomotor performance were evaluated. RESULTS: Neither endurance time nor post-exercise bronchodilation were significantly different between the treatments. Metabolic parameters were affected by exercise but not by treatment. CONCLUSIONS: Inhaled salbutamol, even in a high dose, did not have a significant effect on endurance performance in non-asthmatic athletes, although the bronchodilating effect of the drug at the beginning of exercise may have improved respiratory adaptation. Our results do not preclude an ergogenic effect of beta2 agonists given by other routes or for a longer period. |
| | |
Authors:
|
C Goubault; M C Perault; E Leleu; S Bouquet; P Legros; B Vandel; A Denjean |
Related Documents
:
|
8315226 - Effect of aging on changes in plasma potassium during exercise. 9707696 - Creatine supplementation in athletes: benefits and potential risks. 1861476 - Are high-performance young women athletes doomed to become low-performance old wives? a... 12569206 - The relationship of left ventricular to femoral artery structure in male athletes. 11438386 - Excitotoxic preconditioning elicited by both glutamate and hypoxia and abolished by lac... 15332346 - Thermoregulation during mild exercise at different circadian times. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Thorax Volume: 56 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 2001 Sep |
Date Detail:
|
Created Date: 2001-08-21 Completed Date: 2001-10-11 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
|
Languages: eng Pagination: 675-9 Citation Subset: IM |
Affiliation:
|
Service d'Explorations Fonctionnelles, Physiologie Respiratoire et de l'Exercice, CHU de Poitiers, 86021 Poitiers, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Inhalation Adult Albuterol / administration & dosage* Bronchodilator Agents / administration & dosage* Cross-Over Studies Double-Blind Method Exercise / physiology* Humans Oxygen Consumption / drug effects Physical Endurance / drug effects Prospective Studies Respiratory Function Tests Sports / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Bronchodilator Agents; 18559-94-9/Albuterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-Pseudomonas aeruginosa antibody detection in patients with bronchiectasis without cystic fibros...
Next Document: Airway function at one year: association with premorbid airway function, wheezing, and maternal smok...