Document Detail


Effects of inhaled salbutamol in exercising non-asthmatic athletes.
MedLine Citation:
PMID:  11514686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Beta-2 agonists such as salbutamol are used, not only by asthmatic athletes to prevent exercise induced asthma, but also by non-asthmatic athletes as a potentially ergogenic agent. We have investigated whether inhaled salbutamol enhances endurance performance in non-asthmatic athletes. METHODS: A prospective double blind, randomised, three way crossover design was used to study the effects of 200 microg and 800 microg inhaled salbutamol versus a placebo in 12 trained triathletes. The treatments were compared in three identical cycle ergometer sessions at 85% of the predetermined maximal oxygen uptake. Lung function, endurance time, metabolic parameters (glucose, potassium, lactate, free fatty acid, and glycerol), and psychomotor performance were evaluated. RESULTS: Neither endurance time nor post-exercise bronchodilation were significantly different between the treatments. Metabolic parameters were affected by exercise but not by treatment. CONCLUSIONS: Inhaled salbutamol, even in a high dose, did not have a significant effect on endurance performance in non-asthmatic athletes, although the bronchodilating effect of the drug at the beginning of exercise may have improved respiratory adaptation. Our results do not preclude an ergogenic effect of beta2 agonists given by other routes or for a longer period.
Authors:
C Goubault; M C Perault; E Leleu; S Bouquet; P Legros; B Vandel; A Denjean
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  56     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-10-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  675-9     Citation Subset:  IM    
Affiliation:
Service d'Explorations Fonctionnelles, Physiologie Respiratoire et de l'Exercice, CHU de Poitiers, 86021 Poitiers, France.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Albuterol / administration & dosage*
Bronchodilator Agents / administration & dosage*
Cross-Over Studies
Double-Blind Method
Exercise / physiology*
Humans
Oxygen Consumption / drug effects
Physical Endurance / drug effects
Prospective Studies
Respiratory Function Tests
Sports / physiology*
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 18559-94-9/Albuterol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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