Document Detail

Effects of inhaled nitrous oxide 50% on estimated cerebral perfusion pressure and zero flow pressure in healthy volunteers.
MedLine Citation:
PMID:  15644008     Owner:  NLM     Status:  MEDLINE    
The role of vascular tone in determining cerebral perfusion pressure is increasingly being appreciated. It has been suggested that zero flow pressure, the arterial pressure at which blood flow ceases, represents the effective downstream pressure of the cerebral circulation. Nitrous oxide is a cerebral vasodilator and may therefore decrease zero flow pressure and increase cerebral perfusion pressure. However, these effects may be opposed by the increase in intracranial blood volume produced by cerebral vasodilation. We studied eight healthy volunteers at normocapnia and studied the effects of the inhalation of nitrous oxide 50% on estimated cerebral perfusion pressure and zero flow pressure using transcranial Doppler ultrasonography. We found that nitrous oxide 50% significantly increased estimated cerebral perfusion pressure (p = 0.03), whilst decreasing zero flow pressure (p = 0.01). These results suggest that the vasomotor effects of nitrous oxide predominate in determining the effective downstream pressure of the cerebral circulation in healthy individuals.
S M Hancock; J R Eastwood; R P Mahajan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anaesthesia     Volume:  60     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-01-12     Completed Date:  2005-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  AIM; IM    
Department of Anaesthesia, C Floor East Block, Queen's Medical Centre, Nottingham NG7 2UH, UK.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Blood Pressure / drug effects
Carbon Dioxide / analysis
Cerebrovascular Circulation / drug effects*
Middle Aged
Middle Cerebral Artery / drug effects,  physiology,  ultrasonography
Nitrous Oxide / pharmacology*
Ultrasonography, Doppler, Transcranial
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Vasodilator Agents; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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