| Effects of inhaled nitrous oxide 50% on estimated cerebral perfusion pressure and zero flow pressure in healthy volunteers. | |
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MedLine Citation:
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PMID: 15644008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of vascular tone in determining cerebral perfusion pressure is increasingly being appreciated. It has been suggested that zero flow pressure, the arterial pressure at which blood flow ceases, represents the effective downstream pressure of the cerebral circulation. Nitrous oxide is a cerebral vasodilator and may therefore decrease zero flow pressure and increase cerebral perfusion pressure. However, these effects may be opposed by the increase in intracranial blood volume produced by cerebral vasodilation. We studied eight healthy volunteers at normocapnia and studied the effects of the inhalation of nitrous oxide 50% on estimated cerebral perfusion pressure and zero flow pressure using transcranial Doppler ultrasonography. We found that nitrous oxide 50% significantly increased estimated cerebral perfusion pressure (p = 0.03), whilst decreasing zero flow pressure (p = 0.01). These results suggest that the vasomotor effects of nitrous oxide predominate in determining the effective downstream pressure of the cerebral circulation in healthy individuals. |
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Authors:
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S M Hancock; J R Eastwood; R P Mahajan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anaesthesia Volume: 60 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-12 Completed Date: 2005-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: England |
Other Details:
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Languages: eng Pagination: 129-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia, C Floor East Block, Queen's Medical Centre, Nottingham NG7 2UH, UK. sally.hancock@nottingham.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anesthetics, Inhalation / pharmacology* Blood Pressure / drug effects Carbon Dioxide / analysis Cerebrovascular Circulation / drug effects* Female Humans Male Middle Aged Middle Cerebral Artery / drug effects, physiology, ultrasonography Nitrous Oxide / pharmacology* Ultrasonography, Doppler, Transcranial Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Vasodilator Agents; 10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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