Document Detail

Effects of inhaled nebulized morphine on ventilation and breathlessness during exercise in healthy man.
MedLine Citation:
PMID:  7789047     Owner:  NLM     Status:  MEDLINE    
1. Nebulized inhaled morphine has been reported to increase exercise endurance in patients with chronic lung disease and to relieve dyspnoea in patients with malignant disease. Potential mechanisms include a central effect occurring after systemic drug absorption or a local action mediated by receptors in the lung. 2. The ventilatory effects of nebulized morphine (10 and 25 mg) were therefore compared with those of intravenous morphine (1.0 and 2.5 mg) and placebo in a double-blind study involving 12 young healthy males. Submaximal cycle ergometry with respiratory gas analysis was performed 15 min after drug administration and breathlessness assessed using a linear visual analogue scale. 3. Neither dose of inhaled morphine had statistically significant effects on spirometry, heart rate, ventilation, respiratory gases or breathlessness at any level of exercise. The slopes and intercepts of the lines relating ventilation to breathlessness were also unaffected. 4. Intravenous morphine 2.5 mg reduced breathlessness slightly at the highest equivalent workload [mean (least significant range) 33 mm (26-40 mm)] compared with placebo [41 mm (34-48 mm), P < 0.05] but had no other significant effects. 5. These results do not support the hypothesis that intrapulmonary opiate receptors modulate the sensation of breathlessness in healthy man. The possibility that inhaled morphine may affect breathlessness caused by other factors, such as disease, has not been excluded.
A R Masood; M M Subhan; J W Reed; S H Thomas
Related Documents :
19020137 - Oxygen consumption of a pneumatically controlled ventilator in a field anesthesia machine.
25157657 - Acute and chronic effects of resistance exercise on the testosterone and cortisol respo...
21959097 - Pre-operative interventions (non-surgical and non-pharmacological) for patients with hi...
2277737 - Surfactant protein-a in bronchoalveolar lavage fluid from neonates with rds on conventi...
20581697 - Effect of core stability training on throwing velocity in female handball players.
9238377 - Exercise recordings for the detection of t wave alternans. promises and pitfalls.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  88     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  447-52     Citation Subset:  IM; S    
Department of Physiological Sciences, University of Newcastle, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Double-Blind Method
Drug Administration Schedule
Exercise / physiology*
Injections, Intravenous
Morphine / administration & dosage*,  pharmacology
Respiration / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sympathoadrenal responses to bronchoconstriction in asthma: an invasive and kinetic study of plasma ...
Next Document:  Is voluntary control of breathing impaired in patients with chronic obstructive pulmonary disease?