| Effects of inhaled Linalool in anxiety, social interaction and aggressive behavior in mice. | |
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MedLine Citation:
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PMID: 19962290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aromatherapy uses essential oils (EOs) for several medical purposes, including relaxation. The association between the use of aromas and a decrease in anxiety could be a valuable instrument in managing anxiety in an ever increasing anxiogenic daily life style. Linalool is a monoterpene commonly found as the major volatile component of EOs in several aromatic plant species. Adding to previously reported sedative effects of inhaled linalool, the aim of this study was to investigate the effects of inhaled linalool on anxiety, aggressiveness and social interaction in mice. Additionally, we investigated the effects of inhaled linalool on the acquisition phase of a step-down memory task in mice. Inhaled linalool showed anxiolytic properties in the light/dark test, increased social interaction and decreased aggressive behavior; impaired memory was only seen the higher dose of linalool. These results strengthen the suggestion that inhaling linalool rich essential oils can be useful as a mean to attain relaxation and counteract anxiety. |
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Authors:
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V M Linck; A L da Silva; M Figueiró; E B Caramão; P R H Moreno; E Elisabetsky |
Publication Detail:
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Type: Journal Article Date: 2009-12-03 |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 17 ISSN: 1618-095X ISO Abbreviation: Phytomedicine Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
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Languages: eng Pagination: 679-83 Citation Subset: IM |
Copyright Information:
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(c) 2009 Elsevier GmbH. All rights reserved. |
Affiliation:
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Laboratório de Etnofarmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aggression / drug effects* Animals Anti-Anxiety Agents / pharmacology, therapeutic use* Anxiety / drug therapy Aromatherapy* Behavior, Animal / drug effects* Darkness Light Male Memory / drug effects Mice Monoterpenes / adverse effects, pharmacology, therapeutic use* Oils, Volatile / pharmacology, therapeutic use* Plant Extracts / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Monoterpenes; 0/Oils, Volatile; 0/Plant Extracts; 78-70-6/linalool |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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