Document Detail

Effects of inhalation of albuterol sulphate, ipratroprium bromide and frusemide on breathing mechanics and gas exchange in healthy exercising horses.
MedLine Citation:
PMID:  11352354     Owner:  NLM     Status:  MEDLINE    
The possibility that pre-exercise inhalation of a bronchodilator by healthy horses could improve their mechanics of breathing and enhance performance was investigated. Ipratropium bromide (0.35 microg/kg bwt; n = 7) was administered by nebulisation 30 min before exercise and frusemide (1 mg/kg bwt; n = 6) was given in the same manner 2 h before exercise. Albuterol sulphate (360 and 720 microg; n = 7) were administered with a metered dose inhaler 2 h before exercise. Each drug was investigated independently of the others using cross-over protocols. Horses completed incremental exercise tests and oxygen consumption, carbon dioxide production, arterial blood gases, heart rate and measures of breathing mechanics including total pulmonary resistance (RL) and nasopharyngeal resistance (RU) were determined for each exercise intensity. The resistance of the lower airways was calculated subsequently from the difference between RL and RU. None of the drugs tested had an effect on any of the variables measured, possibly because maximal bronchodilation is stimulated in healthy horses by the normal sympathoadrenergic response to exercise. Therefore, the pre-exercise inhalation of a bronchodilator by a healthy horse is unlikely to improve performance capacity.
W M Bayly; R F Slocombe; H C Schott; M T Hines; R H Sides; J E Hakala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  33     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-12-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  302-10     Citation Subset:  IM    
Department of Veterinary Clinical Sciences, Washington State University Pullman, USA.
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MeSH Terms
Albuterol / pharmacology
Bronchodilator Agents / pharmacology*
Cross-Over Studies
Diuretics / pharmacology*
Furosemide / pharmacology
Horses / physiology*
Ipratropium / pharmacology
Nebulizers and Vaporizers / veterinary
Oxygen Consumption / drug effects
Physical Conditioning, Animal
Pulmonary Gas Exchange / drug effects*,  physiology
Respiratory Mechanics / drug effects*,  physiology
Vascular Resistance / drug effects
Reg. No./Substance:
0/Bronchodilator Agents; 0/Diuretics; 18559-94-9/Albuterol; 54-31-9/Furosemide; 60205-81-4/Ipratropium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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