Document Detail

Effects of an ingested glutamate arginine salt on ammonemia during and after long lasting cycling.
MedLine Citation:
PMID:  8000036     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to examine the effect of glutamate-arginine salt (AGs) or placebo (P1) on ammonemia during and after 1 hour exercise on sporting event bicycle under ergonomic device at 80% VO2max in 3 healthy male volunteers (age 18-25 years). Subjects were tested in three sessions, at rest after AGs and during exercise with placebo (Pl) or AGs. The subjects were given 20 g of AGs or Pl orally and 30 min later, exercised at 75-80% VO2max for 30 min. Blood samples were taken at 0, +30, +60, +90, +120 min after AGs and analyzed for ammonemia. Our results show a highly significant increase in plasma ammonia concentration during exercise. The magnitude of this increase was diminished when subjects were given AGs before the exercise session, suggesting that AGs may help reduce physiologic fatigue.
B Eto; G Peres; G Le Moel
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives internationales de physiologie, de biochimie et de biophysique     Volume:  102     ISSN:  0778-3124     ISO Abbreviation:  Arch Int Physiol Biochim Biophys     Publication Date:    1994 May-Jun
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111069     Medline TA:  Arch Int Physiol Biochim Biophys     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  161-2     Citation Subset:  IM    
Laboratoire de Physiologie, Faculté de Médecine Pitié Salpêtrière, Paris, France.
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MeSH Terms
Ammonia / blood*
Arginine / administration & dosage,  pharmacology*
Exercise / physiology
Glutamic Acid / administration & dosage,  pharmacology*
Oxygen Consumption
Reg. No./Substance:
56-86-0/Glutamic Acid; 74-79-3/Arginine; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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