| Effects of infusion of L-arginine on exercise-induced myocardial ischemic ST-segment changes and capacity to exercise of patients with stable angina pectoris. | |
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MedLine Citation:
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PMID: 10421972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Results of recent studies show that intracoronary administration of L-arginine, the precursor of nitric oxide, restores endothelial function in subjects with coronary risk factors and minimal coronary artery lesions. However, few investigators have examined the clinical feasibility of using L-arginine for treatment of myocardial ischemia due to coronary artery disease. OBJECTIVE: To examine the effect of supplementary L-arginine on exercise-induced myocardial ischemia and capacity to exercise of patients with stable effort angina pectoris. METHODS: Twelve patients confirmed to have a single epicardial coronary artery stenosis underwent two treadmill exercise tests after infusion of 10% L-arginine solution or placebo (5% dextrose) according to a randomized single-blind crossover design on two days separated by an interval of less than 1 week. Respiratory gas exchange kinetics were measured and myocardial ischemia was estimated by electrocardiography before and during exercise. RESULTS: Infusion of L-arginine did not alter exercise-induced changes in heart rate and blood pressure, and objective parameters of capacity to exercise. Exercise-induced maximum ST-segment depression (by 2.1 +/- 0.9 mm; with L-arginine; by 1.9 +/- 0.9 mm with placebo, NS) and onset of 1 mm ST-segment depression after exercise (after 261 +/- 131 s with L-arginine; after 247 +/- 136 s with placebo, NS) also remained unchanged. However, ST-segment depression was restored to baseline after exercise significantly more quickly after infusion of L-arginine than it did with placebo (after 331 +/- 167 s with L-arginine; after 400 +/- 165 s with placebo: P < 0.01). CONCLUSION: Intravenous administration of L-arginine did not alter capacity to exercise or the threshold for exercise-induced myocardial ischemia. However, it did reduce the time taken for recovery after ST-segment depression, suggesting that an earlier resolution of exercise-induced myocardial ischemia occurred. |
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Authors:
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N Kobayashi; M Nakamura; K Hiramori |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Coronary artery disease Volume: 10 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-20 Completed Date: 1999-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 321-6 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / drug therapy, physiopathology* Arginine / administration & dosage, therapeutic use* Electrocardiography Exercise Test Exercise Tolerance / drug effects* Female Humans Infusions, Intravenous Male Myocardial Ischemia / physiopathology* Nitric Oxide / physiology |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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