| Effects of infused sodium acetate, sodium lactate, and sodium beta-hydroxybutyrate on energy expenditure and substrate oxidation rates in lean humans. | |
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MedLine Citation:
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PMID: 8237864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infusion of sodium acetate in lean humans results in a decrease in respiratory exchange ratio, which may be advantageous in patients with respiratory failure. However, this potential decrease in respiratory work was observed to be offset by significant thermogenesis. The metabolic effects of sodium acetate, sodium lactate, and sodium beta-hydroxybutyrate, infused at a rate of 20 mumol.kg-1.min-1 for 3 h, was monitored in six healthy human volunteers. Respiratory exchange ratio decreased from 0.85 +/- 0.02 at baseline to 0.75 +/- 0.02, 0.75 +/- 0.02, and 0.80 +/- 0.02, after acetate, lactate, or beta-hydroxybutyrate, respectively (P < 0.05 for each). Acetate produced a larger thermic effect (22.7% of energy infused) than did lactate (16.3%) or beta-hydroxybutyrate (13.6%). Thus, sodium salts of organic acids may potentially decrease the respiratory requirements by decreasing the respiratory exchange ratio. However, this effect is partially offset by the thermic effect of these substrates. The maximal doses and safety of these anions during larger infusion periods remain to be determined. |
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Authors:
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R Chioléro; P Mavrocordatos; P Burnier; M C Cayeux; C Schindler; E Jéquier; L Tappy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 58 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-11-29 Completed Date: 1993-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 608-13 Citation Subset: AIM; IM |
Affiliation:
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Surgical Intensive Care Unit, Centre Hospitalier Universitaire Vaudois, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid Acetic Acid Acetic Acids / pharmacology* Adult Energy Metabolism / drug effects* Female Humans Hydroxybutyrates / pharmacology* Infusions, Intravenous Lactates / pharmacology* Lactic Acid Male Models, Theoretical Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Hydroxybutyrates; 0/Lactates; 300-85-6/3-Hydroxybutyric Acid; 50-21-5/Lactic Acid; 64-19-7/Acetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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