| Effects induced by two different estrogens on serum individual phospholipids and serum lecithin fatty acid composition. | |
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MedLine Citation:
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PMID: 7239424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eleven oophorectomized women (mean age 34.5 +/- 5.9) received two treatment cycles, one of the 17-C-alkylated ethinyl estradiol 20 microgram per day, and the second of the non-alkylated estrogen, estradiol valerate 2 mg per day for six weeks in separate periods preceded by six weeks without hormonal replacement therapy. Blood samples were drawn before and after six weeks on each estrogen. The samples were assayed for individual phospholipids i.e. cephalin, lecithin, lysolecithin and sphingomyelin after separation of these lipids by thin layer chromatography. The relative fatty acid composition of serum and high density lipoprotein lecithin and serum cholesterol ester was determined by gas liquid chromatography. Both estrogens reversed the symptoms of estrogen deficiency and had similar effects on serum individual phospholipids i.e. causing an increase in lecithin concomitant with a decrease in lysolecithin. It is suggested that this lecithin-lysolecithin shift could depend on an inhibition of the hepatic lipase and its phospholipase A1-activity. Both estrogens increased serum lecithin arachidonic acid without causing any change in linoleic acid (the major essential fatty acid), which indicates that this increase in arachidonic acid could be an estrogenic effect independent of dietary factors. Ethinyl estradiol caused an increase in palmitic and a decrease in stearic acid in the 1-position of serum lecithin while estradiol valerate did not influence these fatty acids at all. This palmitic-stearic acid shift induced by ethinyl estradiol is interpreted as a non-hormonal "drug-effect" linked to the liver toxicity of 17-C-alkylated steroids in spite of the lack of influence on routine liver function tests. |
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Authors:
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G Silfverstolpe; P Johnson; G Samsice; A Svanborg; A Gustafson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 13 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 141-5 Citation Subset: IM; J |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arachidonic Acids / blood Castration Cholesterol Esters / blood Estradiol / pharmacology* Ethinyl Estradiol / pharmacology* Fatty Acids / blood Female Humans Lipoproteins, LDL / blood Middle Aged Phosphatidylcholines / blood* Phospholipids / blood* |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Cholesterol Esters; 0/Fatty Acids; 0/Lipoproteins, LDL; 0/Phosphatidylcholines; 0/Phospholipids; 50-28-2/Estradiol; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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