| Effects of indomethacin and naproxen on renal p-amino-hippurate (PAH) excretion in rats during postnatal development. | |
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MedLine Citation:
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PMID: 6428338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of the cyclooxygenase inhibitors indomethacin and naproxen on renal PAH excretion were studied in volume-expanded and sodium-loaded, conscious rats of different ages. Indomethacin and naproxen reduce renal PAH excretion in 5- and 10-day-old rats but not in rats of older ages. Findings can be explained by a decrease in glomerular filtration rate. In addition, a competitive inhibition of PAH transport by the organic acids indomethacin and naproxen must be mentioned. Until now it is not known whether or not there is a direct or indirect influence of prostaglandins on processes involved in tubular PAH transport. |
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Authors:
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C Hably; K Banki; J Bartha; H Bräunlich |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 268 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-07-02 Completed Date: 1984-07-02 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 4-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Aminohippuric Acids / urine* Animals Diuresis / drug effects Female Glomerular Filtration Rate Hematocrit Indomethacin / pharmacology* Male Naproxen / pharmacology* Prostaglandin-Endoperoxide Synthases / metabolism Rats Rats, Inbred Strains Sodium / metabolism p-Aminohippuric Acid / urine* |
| Chemical | |
Reg. No./Substance:
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0/Aminohippuric Acids; 22204-53-1/Naproxen; 53-86-1/Indomethacin; 61-78-9/p-Aminohippuric Acid; 7440-23-5/Sodium; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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