Document Detail

Effects of indomethacin on hepatogenic pulmonary angiodysplasia.
MedLine Citation:
PMID:  2009756     Owner:  NLM     Status:  MEDLINE    
A patient had liver cirrhosis associated with marked hypoxemia. With administration of indomethacin (75 mg/day for six days), PaO2 was elevated up to 50 mm Hg from 44 mm Hg. At that time, dynamic pulmonary perfusion imaging revealed a plateau time course curve of MAA uptake in the lungs, as compared with findings obtained during the state of severe hypoxemia without indomethacin. These observations suggest that part of hepatogenic pulmonary angiodysplasia is a functional vasodilatation that is presumably modulated by vasoactive substances, such as prostaglandins and/or other eicosanoids.
H Shijo; H Sasaki; K Yuh; S Sakaguchi; M Okumura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  99     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-06     Completed Date:  1991-05-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1027-9     Citation Subset:  AIM; IM    
First Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
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MeSH Terms
Anoxia / drug therapy*,  etiology
Arteriovenous Fistula / etiology*,  radionuclide imaging
Indomethacin / therapeutic use*
Liver Cirrhosis / complications*
Lung / radionuclide imaging
Lung Diseases / etiology*,  radionuclide imaging
Middle Aged
Pulmonary Artery
Pulmonary Veins
Technetium Tc 99m Aggregated Albumin / diagnostic use
Vasodilation / drug effects*
Reg. No./Substance:
0/Technetium Tc 99m Aggregated Albumin; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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