| Effects of indomethacin and etodolac on coronary blood flow and other cardiovascular variables in propranolol-treated dogs. | |
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MedLine Citation:
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PMID: 3161477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Indomethacin has been reported to induce coronary vasoconstriction in patients treated with beta-adrenoceptor blockers and nitrates. In the present investigation, the possibility that coronary blood flow was affected by a direct or indirect interaction between nonsteroidal anti-inflammatory drugs and propranolol was studied in the anesthetized dog. During beta-adrenoceptor blockade by propranolol, both indomethacin and etodolac failed to decrease coronary blood flow. When administered alone at doses sufficient to inhibit prostaglandin synthesis, indomethacin and etodolac did not reduce the coronary blood flow. It was concluded that there was no interaction between propranolol and the nonsteroidal anti-inflammatory drugs used. The results also suggested that the role of prostaglandins in the regulation of the coronary circulation remains an open question. |
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Authors:
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G Beaulieu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 274 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-09-19 Completed Date: 1985-09-19 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 283-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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pharmacology* Animals Anti-Inflammatory Agents / pharmacology* Blood Pressure / drug effects Cardiac Output / drug effects Coronary Circulation / drug effects* Dogs Etodolac Heart Rate / drug effects Hemodynamics / drug effects* Indomethacin / pharmacology* Propranolol / pharmacology* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 0/Anti-Inflammatory Agents; 41340-25-4/Etodolac; 525-66-6/Propranolol; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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