Document Detail

Effects of indomethacin on cerebral haemodynamics in very preterm infants.
MedLine Citation:
PMID:  1972434     Owner:  NLM     Status:  MEDLINE    
Near infrared spectroscopy was used to investigate the effects of intravenously administered indomethacin (0.1-0.2 mg/kg) on cerebral haemodynamics and oxygen delivery in 13 very preterm infants treated for patent ductus arteriosus. 7 infants received indomethacin by rapid injection (30 s) and 6 by slow infusion (20-30 min). In all the infants cerebral blood flow, oxygen delivery, blood volume, and the reactivity of blood volume to changes in arterial carbon dioxide tension fell sharply after indomethacin. There were no differences in the effects of rapid and slow infusion. These falls in cerebral oxygen delivery and the disruption of cerebrovascular control might compromise cellular oxygen availability, particularly in regions of the brain where the arterial supply is precarious. Care should be taken to ensure that oxygen delivery is optimum before the administration of indomethacin to preterm infants.
A D Edwards; J S Wyatt; C Richardson; A Potter; M Cope; D T Delpy; E O Reynolds
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  335     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-24     Completed Date:  1990-07-24     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1491-5     Citation Subset:  AIM; IM    
Department of Paediatrics, University College and Middlesex School of Medicine, London, UK.
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MeSH Terms
Blood Gas Monitoring, Transcutaneous*
Blood Pressure / drug effects
Blood Volume / drug effects*
Cerebrovascular Circulation / drug effects*
Drug Evaluation
Ductus Arteriosus, Patent / blood,  physiopathology*
Indomethacin / administration & dosage,  pharmacology*
Infant, Newborn
Infant, Premature, Diseases / blood,  physiopathology*
Infusions, Intravenous / methods
Spectrophotometry, Infrared / instrumentation
Grant Support
//Wellcome Trust
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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