| Effects of indomethacin on cerebral haemodynamics in very preterm infants. | |
| | |
MedLine Citation:
|
PMID: 1972434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Near infrared spectroscopy was used to investigate the effects of intravenously administered indomethacin (0.1-0.2 mg/kg) on cerebral haemodynamics and oxygen delivery in 13 very preterm infants treated for patent ductus arteriosus. 7 infants received indomethacin by rapid injection (30 s) and 6 by slow infusion (20-30 min). In all the infants cerebral blood flow, oxygen delivery, blood volume, and the reactivity of blood volume to changes in arterial carbon dioxide tension fell sharply after indomethacin. There were no differences in the effects of rapid and slow infusion. These falls in cerebral oxygen delivery and the disruption of cerebrovascular control might compromise cellular oxygen availability, particularly in regions of the brain where the arterial supply is precarious. Care should be taken to ensure that oxygen delivery is optimum before the administration of indomethacin to preterm infants. |
| | |
Authors:
|
A D Edwards; J S Wyatt; C Richardson; A Potter; M Cope; D T Delpy; E O Reynolds |
Related Documents
:
|
2288214 - Cerebral and abdominal arterial hemodynamics in preterm infants with patent ductus arte... 7114004 - Intravenous indomethacin therapy in premature infants with patent ductus arteriosus. ca... 1549074 - Nonnutritive sucking: adaptation and health for the neonate. 3087674 - Hemodynamic variables in infants weighing less than 1000 grams. 17417714 - Problem behavior in a community sample of 14- and 19-month-old children: common versus ... 16373294 - Increase of interleukin-6 in tracheal aspirate at birth: a predictor of subsequent bron... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Lancet Volume: 335 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1990 Jun |
Date Detail:
|
Created Date: 1990-07-24 Completed Date: 1990-07-24 Revised Date: 2009-09-29 |
Medline Journal Info:
|
Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1491-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Paediatrics, University College and Middlesex School of Medicine, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Gas Monitoring, Transcutaneous* Blood Pressure / drug effects Blood Volume / drug effects* Cerebrovascular Circulation / drug effects* Drug Evaluation Ductus Arteriosus, Patent / blood, physiopathology* Female Humans Indomethacin / administration & dosage, pharmacology* Infant, Newborn Infant, Premature, Diseases / blood, physiopathology* Infusions, Intravenous / methods Male Spectrophotometry, Infrared / instrumentation |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in c...
Next Document: Hepatobiliary and pancreatic ascariasis in India.