| Effects of indomethacin on acute, subacute, and latent infections in mice and rats. | |
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MedLine Citation:
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PMID: 5663575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The comparative effect of indomethacin and hydrocortisone on the resistance of mice or rats to various acute, subacute, and latent bacterial infections was investigated. Large daily doses of indomethacin and hydrocortisone administered to mice challenged with bacterial pathogens, including Klebsiella pneumoniae AD, Salmonella schottmuelleri 3010, Staphylococcus aureus (Smith), Streptococcus pyogenes C203, Salmonella pullorum #2, Proteus vulgaris 1810, and Pseudomonas aeruginosa 2616, revealed that in essentially all of these acute infections, the mortality of the infected mice treated with indomethacin was essentially identical to that found in the infected controls. In contrast, hydrocortisone often lowered the resistance of mice to these acute infections. In a more chronic bacterial infection due to Corynebacterium kutscheri, hydrocortisone produced striking deleterious effects on resistance, whereas indomethacin administration in doses approaching the maximal tolerated level caused no observable adverse effects on host resistance. Indomethacin fed continuously to rats for 80 days, at maximal tolerated levels, caused no observable adverse effects on the host-parasite relationship of rats which were shown to harbor various latent infections. Hydrocortisone administration, however, lowered the resistance of rats as evidenced by increased mortality related directly to extensive bacterial infection. Insofar as infection is concerned, indomethacin behaved like other nonsteroid anti-inflammatory agents such as aspirin and phenylbutazone. |
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Authors:
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H J Robinson; H F Phares; O E Graessle |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of bacteriology Volume: 96 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1968 Jul |
Date Detail:
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Created Date: 1968-09-13 Completed Date: 1968-09-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Corynebacterium Female Hydrocortisone / adverse effects* Indomethacin / adverse effects* Infection / etiology* Klebsiella Infections / etiology Male Mice Proteus Infections / etiology Rats Salmonella Infections, Animal / etiology Staphylococcal Infections / etiology Streptococcal Infections / etiology |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone; 53-86-1/Indomethacin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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