Document Detail

Effects of increasing left ventricular filling. Pressure in patients with acute myocardial infarction.
MedLine Citation:
PMID:  5431663     Owner:  NLM     Status:  MEDLINE    
Left ventricular performance in 19 patients with acute myocardial infarction has been evaluated by measuring left ventricular response in terms of cardiac output, stroke volume, work, and power to progressive elevation of filling pressure accomplished by progressive expansion of blood volume with rapid infusion of low molecular weight dextran. Such infusion can elevate the cardiac output, stroke volume, work, and power and thus delineate the function of the left ventricle by Frank-Starling function curves. Left ventricular filling pressure in the range of 20-24 mm Hg was associated with the peak of the curves and when the filling pressure exceeded this range, the curves became flattened or decreased. An increase in cardiac output could be maintained for 4 or more hr. Patients with a flattened function curve had a high mortality in the ensuing 8 wk. The function curve showed improvement in myocardial function during the early convalescence. When left ventricular filling pressure is monitored directly or as pulmonary artery end-diastolic pressure, low molecular weight dextran provides a method for assessment of left ventricular function.
R O Russell; C E Rackley; J Pombo; D Hunt; C Potanin; H T Dodge
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  49     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1970 Aug 
Date Detail:
Created Date:  1970-09-09     Completed Date:  1970-09-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1539-50     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Blood Volume
Cardiac Output
Heart Catheterization
Heart Function Tests
Heart Ventricles / physiopathology*
Hydrogen-Ion Concentration
Myocardial Infarction / physiopathology*
Plasma Substitutes
Pulmonary Artery
Reg. No./Substance:
0/Plasma Substitutes; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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