Document Detail

Effects of increased pulmonary vascular tone on gas exchange in canine oleic acid pulmonary edema.
MedLine Citation:
PMID:  3170419     Owner:  NLM     Status:  MEDLINE    
Pulmonary gas exchange was investigated before and after an increase in pulmonary vascular tone induced by administration of acetylsalicylic acid (ASA), indomethacin, or almitrine in 32 pentobarbital-anesthetized and ventilated (fraction of inspired O2 0.4) dogs with oleic acid lung injury. Pulmonary vascular tone was evaluated by five-point pulmonary arterial pressure (PAP)/cardiac index (Q) plots and intrapulmonary shunt was measured using a SF6 infusion. PAP/Q plots were rectilinear in all experimental conditions. In control dogs (n = 8), oleic acid (0.09 ml/kg iv) increased PAP over the range of Q studied (1-5 l.min-1.m-2). At the same Q, arterial PO2 fell from 186 +/- 11 to 65 +/- 8 (SE) Torr and intrapulmonary shunt rose from 5 +/- 1 to 50 +/- 6% 90 min after oleic acid injection. These changes remained stable during the generation of two consecutive PAP/Q plots. ASA (1 g iv, n = 8), indomethacin (2 mg/kg iv, n = 8), and almitrine (8 iv, n = 8) produced a further increase in PAP at each level of Q. ASA and indomethacin, respectively, increased arterial PO2 from 61 +/- 4 to 70 +/- 3 Torr (P less than 0.05) and from 70 +/- 6 to 86 +/- 6 Torr (P less than 0.05) and decreased intrapulmonary shunt from 61 +/- 5 to 44 +/- 4% (P less than 0.05) and from 44 +/- 5 to 29 +/- 4% (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
M Leeman; P Lejeune; R Hallemans; C Mélot; R Naeije
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  65     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-22     Completed Date:  1988-11-22     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  662-8     Citation Subset:  IM    
Respiratory Research Unit, Erasme University Hospital, Brussels, Belgium.
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MeSH Terms
Aspirin / administration & dosage,  pharmacology*
Blood Gas Analysis
Blood Pressure
Cardiac Output
Indomethacin / pharmacology
Lung / blood supply*,  drug effects,  physiopathology
Oleic Acid
Oleic Acids
Oxygen / blood
Piperazines / pharmacology
Pulmonary Edema / chemically induced,  physiopathology*
Pulmonary Gas Exchange*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Oleic Acids; 0/Piperazines; 112-80-1/Oleic Acid; 27469-53-0/Almitrine; 50-78-2/Aspirin; 53-86-1/Indomethacin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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