Document Detail


Effects of increased pressure inside or outside ventricles on total and regional myocardial blood flow.
MedLine Citation:
PMID:  11087249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increasing pressures to 30 mmHg in right (RV) and left (LV) ventricles and surrounding heart (SH) in isolated, arrested, maximally vasodilated, blood-perfused dog hearts shifted pressure-flow (PF) curves rightward and increased zero flow pressure (P(zf)) by an amount equal to the RV applied pressure, SH applied pressure, or two-thirds of the LV applied pressure. There were comparable increases in coronary venous pressures. Increasing LV or SH pressures decreased coronary blood flows, especially in the subendocardium. Decreases in driving pressure decreased flows in all layers, but even with driving pressure of 5 mmHg, a few subepicardial pieces had flow. We conclude with the following: 1) raising pressures inside or outside the heart shifts PF curves and raises P(zf) by increasing coronary venous pressure; 2) the effects are most prominent in the subendocardial muscle layer; and 3) as driving pressures are decreased, there is a range of P(zf) in the heart with the final P(zf) recorded due to the last little piece of muscle to be perfused.
Authors:
G S Aldea; H Mori; W K Husseini; R E Austin; J I Hoffman
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  279     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-15     Completed Date:  2000-12-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H2927-38     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute and the Department of Pediatrics, University of California, San Francisco, California 94143-0544, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Volume / physiology
Coronary Circulation / physiology*
Coronary Vessels / physiology
Dogs
Endocardium / physiology
Perfusion
Pericardium / physiology
Pressure
Ventricular Pressure / physiology*
Grant Support
ID/Acronym/Agency:
HL-07192/HL/NHLBI NIH HHS; HL-25847/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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