| Effects of increased pressure inside or outside ventricles on total and regional myocardial blood flow. | |
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MedLine Citation:
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PMID: 11087249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing pressures to 30 mmHg in right (RV) and left (LV) ventricles and surrounding heart (SH) in isolated, arrested, maximally vasodilated, blood-perfused dog hearts shifted pressure-flow (PF) curves rightward and increased zero flow pressure (P(zf)) by an amount equal to the RV applied pressure, SH applied pressure, or two-thirds of the LV applied pressure. There were comparable increases in coronary venous pressures. Increasing LV or SH pressures decreased coronary blood flows, especially in the subendocardium. Decreases in driving pressure decreased flows in all layers, but even with driving pressure of 5 mmHg, a few subepicardial pieces had flow. We conclude with the following: 1) raising pressures inside or outside the heart shifts PF curves and raises P(zf) by increasing coronary venous pressure; 2) the effects are most prominent in the subendocardial muscle layer; and 3) as driving pressures are decreased, there is a range of P(zf) in the heart with the final P(zf) recorded due to the last little piece of muscle to be perfused. |
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Authors:
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G S Aldea; H Mori; W K Husseini; R E Austin; J I Hoffman |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 279 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-15 Completed Date: 2000-12-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H2927-38 Citation Subset: IM |
Affiliation:
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Cardiovascular Research Institute and the Department of Pediatrics, University of California, San Francisco, California 94143-0544, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Volume / physiology Coronary Circulation / physiology* Coronary Vessels / physiology Dogs Endocardium / physiology Perfusion Pericardium / physiology Pressure Ventricular Pressure / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-07192/HL/NHLBI NIH HHS; HL-25847/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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